UniProt Accession

 G6PI_YEAST; P12709; D6VQJ0 

Genbank Protein ID

 M37267; M21696; X13977; Z21487; Z36065; BK006936 

Genbank Nucleotide ID

 AAA34862.1; AAA34894.1; CAA32158.1; CAA79683.1; CAA85158.1; DAA07310.1 

Protein Name

 Glucose-6-phosphate isomerase 

Protein Synonyms/Alias

 GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI 

Gene Name

 PGI1 

Gene Synonyms/Alias

 YBR196C; YBR1406 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
20	TELPAWSKLQKIYES	acetylation	[1]
23	PAWSKLQKIYESQGK	acetylation	[1]
23	PAWSKLQKIYESQGK	ubiquitination	[2]
30	KIYESQGKTLSVKQE	acetylation	[1]
30	KIYESQGKTLSVKQE	ubiquitination	[2]
35	QGKTLSVKQEFQKDA	acetylation	[1]
35	QGKTLSVKQEFQKDA	ubiquitination	[2]
50	KRFEKLNKTFTNYDG	acetylation	[1]
50	KRFEKLNKTFTNYDG	ubiquitination	[2]
59	FTNYDGSKILFDYSK	acetylation	[1]
59	FTNYDGSKILFDYSK	ubiquitination	[2]
95	GLRDAMFKGEHINST	acetylation	[1]
136	PEVDSVLKHMKEFSE	acetylation	[1]
139	DSVLKHMKEFSEQVR	acetylation	[1]
151	QVRSGEWKGYTGKKI	acetylation	[1]
234	ITNANTAKNWFLSKT	ubiquitination	[2]
240	AKNWFLSKTGNDPSH	acetylation	[1]
250	NDPSHIAKHFAALST	acetylation	[1]
371	LSMESNGKSVTRGNV	ubiquitination	[2]
455	GKDEEQVKAEGATGG	acetylation	[1]
467	TGGLVPHKVFSGNRP	ubiquitination	[2]
524	ELGKVLAKVIGKELD	acetylation	[1]
524	ELGKVLAKVIGKELD	ubiquitination	[2, 3]
528	VLAKVIGKELDNSST	acetylation	[1]
528	VLAKVIGKELDNSST	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [3] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 

Functional Description

  

Sequence Annotation

 ACT_SITE 367 367 Proton donor (By similarity).
 ACT_SITE 398 398 By similarity.
 ACT_SITE 520 520 By similarity.
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 53 53 Phosphothreonine.
 MOD_RES 220 220 Phosphothreonine.  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Gluconeogenesis; Glycolysis; Isomerase; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 554 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0005886; C:plasma membrane; IDA:SGD.
 GO:0004347; F:glucose-6-phosphate isomerase activity; IMP:SGD.
 GO:0006094; P:gluconeogenesis; IMP:SGD.
 GO:0006096; P:glycolysis; IMP:SGD.
 GO:0006098; P:pentose-phosphate shunt; IMP:SGD. 

Interpro

 IPR001672; G6P_Isomerase.
 IPR023096; G6P_Isomerase_C.
 IPR018189; Phosphoglucose_isomerase_CS. 

Pfam

 PF00342; PGI 

SMART

  

PROSITE

 PS00765; P_GLUCOSE_ISOMERASE_1
 PS00174; P_GLUCOSE_ISOMERASE_2
 PS51463; P_GLUCOSE_ISOMERASE_3 

PRINTS

 PR00662; G6PISOMERASE.