| Tag | Content |
|---|
| CPLM ID | CPLM-012885 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Leucine-rich repeat flightless-interacting protein 1 |
Protein Synonyms/Alias | LRR FLII-interacting protein 1; GC-binding factor 2; TAR RNA-interacting protein |
Gene Name | LRRFIP1 |
Gene Synonyms/Alias | GCF2; TRIP |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 633 | VTENPKQKIAAESSE | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. |
Sequence Annotation | REGION 485 584 DNA-binding.
MOD_RES 2 2 N-acetylthreonine.
MOD_RES 16 16 Phosphoserine.
MOD_RES 115 115 Phosphoserine.
MOD_RES 120 120 Phosphoserine.
MOD_RES 123 123 Phosphothreonine (By similarity).
MOD_RES 555 555 Phosphoserine.
MOD_RES 581 581 Phosphoserine.
MOD_RES 618 618 Phosphoserine.
MOD_RES 676 676 Phosphothreonine.
MOD_RES 714 714 Phosphoserine.
MOD_RES 733 733 Phosphoserine.
MOD_RES 766 766 Phosphoserine. |
Keyword | 3D-structure; Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repressor; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 808 AA |
Protein Sequence | MTSPAAAQSR EIDCLSPEAQ KLAEARLAAK RAARAEAREI RMKELERQQK EEDSERYSRR 60
SRRNTSASDE DERMSVGSRG SLRVEERPEK DFTEKGSRNM PGLSAATLAS LGGTSSRRGS 120
GDTSISIDTE ASIREIKELN ELKDQIQDVE GKYMQGLKEM KDSLAEVEEK YKKAMVSNAQ 180
LDNEKTNFMY QVDTLKDMLL ELEEQLAESR RQYEEKNKEF EREKHAHSIL QFQFAEVKEA 240
LKQREEMLEK HGIILNSEIA TNGETSDTLN NVGYQGPTKM TKEELNALKS TGDGTLGRAS 300
EVEVKNEIVA NVGKREILHN TEKEQHTEDT VKDCVDIEVF PAGENTEDQK SSEDTAPFLG 360
TLAGATYEEQ VQSQILESSS LPENTVQVES NEVMGAPDDR TRTPLEPSNC WSDLDGGNHT 420
ENVGEAAVTQ VEEQAGTVAS CPLGHSDDTV YHDDKCMVEV PQELETSTGH SLEKEFTNQE 480
AAEPKEVPAH STEVGRDHNE EEGEETGLRD EKPIKTEVPG SPAGTEGNCQ EATGPSTVDT 540
QNEPLDMKEP DEEKSDQQGE ALDSSQKKTK NKKKKNKKKK SPVPVETLKD VKKELTYQNT 600
DLSEIKEEEQ VKSTDRKSAV EAQNEVTENP KQKIAAESSE NVDCPENPKI KLDGKLDQEG 660
DDVQTAAEEV LADGDTLDFE DDTVQSSGPR AGGEELDEGV AKDNAKIDGA TQSSPAEPKS 720
EDADRCTLPE HESPSQDISD ACEAESTERC EMSEHPSQTV RKALDSNSLE NDDLSAPGRE 780
PGHFNPESRE DTRGGNEKGK SKEDCTMS 808 |
Gene Ontology | GO:0005737; C:cytoplasm; TAS:ProtInc. GO:0005856; C:cytoskeleton; TAS:ProtInc. GO:0005634; C:nucleus; NAS:UniProtKB. GO:0003677; F:DNA binding; IDA:UniProtKB. GO:0003725; F:double-stranded RNA binding; TAS:ProtInc. GO:0042803; F:protein homodimerization activity; IDA:UniProtKB. GO:0045892; P:negative regulation of transcription, DNA-dependent; NAS:UniProtKB. GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |