UniProt Accession

 MB12A_HUMAN; Q96EY5; Q96I18 

Genbank Protein ID

 BC007883; BC011840 

Genbank Nucleotide ID

 AAH07883.2; AAH11840.1 

Protein Name

 Multivesicular body subunit 12A 

Protein Synonyms/Alias

 CIN85/CD2AP family-binding protein; ESCRT-I complex subunit MVB12A; Protein FAM125A 

Gene Name

 MVB12A 

Gene Synonyms/Alias

 CFBP; FAM125A 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
44	GAPASFGKSFAQKSG	ubiquitination	[1]
179	DAASQPSKGGLLERT	ubiquitination	[1, 2]
229	LHPRFEGKSCSPLAF	ubiquitination	[1]
262	NYGFVVEKTAAARLP	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down- regulation of EGF receptor. 

Sequence Annotation

 DOMAIN 9 151 MABP.
 DOMAIN 215 265 UMA.
 REGION 192 273 Interaction with TSG101, VPS37B and
 MOTIF 155 160 SH3-binding.
 MOD_RES 130 130 Phosphothreonine.
 MOD_RES 163 163 Phosphoserine.
 MOD_RES 170 170 Phosphoserine.
 MOD_RES 202 202 Phosphoserine.
 MOD_RES 204 204 Phosphotyrosine.
 MOD_RES 207 207 Phosphoserine.
 MOD_RES 232 232 Phosphoserine.  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Endosome; Membrane; Nucleus; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; SH3-binding; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 273 AA 

Protein Sequence

Gene Ontology

 GO:0016235; C:aggresome; IDA:HPA.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR018798; FAM125.
 IPR023341; MABP.
 IPR023340; UMA. 

Pfam

 PF10240; DUF2464 

SMART

  

PROSITE

 PS51498; MABP
 PS51497; UMA 

PRINTS