CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041029
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Very low-density lipoprotein receptor 
Protein Synonyms/Alias
  
Gene Name
 Vldlr 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
759NWQHKNMKSMNFDNPubiquitination[1]
770FDNPVYLKTTEEDLSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Disulfide bond; EGF-like domain; Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 804 AA 
Protein Sequence
MGTSARWALW LLLALCWAPR DSGATASGKK AKCDSSQFQC TNGRCITLLW KCDGDEDCAD 60
GSDEKNCVKK TCAESDFVCK NGQCVPNRWQ CDGDPDCEDG SDESPEQCRN ITCSADEFTC 120
SSGRCVSRNF VCNGQDDCDD GSDELDCAPP TCGAHEFQCS TSSCIPLSWV CDDDADCSDQ 180
SDESLEQCGR QPVIHTKCPT SEIQCGSGEC IHKKWRCDGD PDCKDGSDEV NCPSRTCRPD 240
QFECEDGSCI HGSRQCNGIR DCVDGSDEVN CKNVNQCLGP GKFKCRSGEC IDMSKVCDQE 300
QDCRDWSDEP LKECHINECL VNNGGCSHIC KDLVIGYECD CAAGFELIDR KTCGDIDECQ 360
NPGICSQICI NLKGGYKCEC SRGYQMDLAT GVCKAVGKEP SLIFTNRRDI RKIGLERKEY 420
IQLVEQLRNT VALDADIAAQ KLFWADLSQK AIFSASIDDK VGRHFKMIDN VYNPAAIAVD 480
WVYKTIYWTD AASKTISVAT LDGAKRKFLF NSDLREPASI AVDPLSGFVY WSDWGEPAKI 540
EKAGMNGFDR RPLVTEDIQW PNGITLDLVK SRLYWLDSKL HMLSSVDLNG QDRRIVLKSL 600
EFLAHPLALT IFEDRVYWID GENEAVYGAN KFTGSELATL VNNLNDAQDI IVYHELVQPS 660
GKNWCEDDME NGGCEYLCLP APQINDHSPK YTCSCPNGYN LEENGRECQR INVTTAVSEV 720
SVPPKGTSAA WAILPLLLLV MAAVGGYLMW RNWQHKNMKS MNFDNPVYLK TTEEDLSIDI 780
GRHSASVGHT YPAISVVSTD DDLA 804 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016020; C:membrane; ISO:MGI.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0045860; P:positive regulation of protein kinase activity; IGI:MGI. 
Interpro
 IPR011042; 6-blade_b-propeller_TolB-like.
 IPR000742; EG-like_dom.
 IPR001881; EGF-like_Ca-bd.
 IPR013032; EGF-like_CS.
 IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
 IPR018097; EGF_Ca-bd_CS.
 IPR009030; Growth_fac_rcpt_N_dom.
 IPR023415; LDLR_class-A_CS.
 IPR000033; LDLR_classB_rpt.
 IPR002172; LDrepeatLR_classA_rpt. 
Pfam
 PF07645; EGF_CA
 PF00057; Ldl_recept_a
 PF00058; Ldl_recept_b 
SMART
 SM00181; EGF
 SM00179; EGF_CA
 SM00192; LDLa
 SM00135; LY 
PROSITE
 PS00010; ASX_HYDROXYL
 PS01186; EGF_2
 PS50026; EGF_3
 PS01187; EGF_CA
 PS01209; LDLRA_1
 PS50068; LDLRA_2
 PS51120; LDLRB 
PRINTS