UniProt Accession

 POC1A_HUMAN; Q8NBT0; A4FUW4; E9PFC6; Q0VDF8; Q2TAK6; Q96IK6; Q9UFJ8 

Genbank Protein ID

 AK075289; AC097637; AC115284; BC007417; BC110877; BC119692; BC119693; AL117629 

Genbank Nucleotide ID

 BAC11525.1; AAH07417.2; AAI10878.1; AAI19693.1; AAI19694.1; CAB56021.1 

Protein Name

 POC1 centriolar protein homolog A 

Protein Synonyms/Alias

 Pix2; WD repeat-containing protein 51A 

Gene Name

 POC1A 

Gene Synonyms/Alias

 WDR51A 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
61	AYRFTGHKDAVTCVN	ubiquitination	[1]
93	RIWVPNVKGESTVFR	ubiquitination	[1, 2]
167	IVSASDDKTVKLWDK	ubiquitination	[1, 2]
170	ASDDKTVKLWDKSSR	ubiquitination	[1]
174	KTVKLWDKSSRECVH	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Required for ciliogenesis. 

Sequence Annotation

 REPEAT 17 56 WD 1.
 REPEAT 59 98 WD 2.
 REPEAT 101 140 WD 3.
 REPEAT 143 182 WD 4.
 REPEAT 185 224 WD 5.
 REPEAT 227 266 WD 6.
 REPEAT 269 308 WD 7.  

Keyword

 Alternative splicing; Cell projection; Ciliopathy; Cilium biogenesis/degradation; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Disease mutation; Dwarfism; Hypotrichosis; Polymorphism; Reference proteome; Repeat; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 407 AA 

Protein Sequence

Gene Ontology

 GO:0005814; C:centriole; IDA:UniProtKB.
 GO:0005932; C:microtubule basal body; IDA:UniProtKB.
 GO:0030030; P:cell projection organization; IEA:UniProtKB-KW. 

Interpro

 IPR020472; G-protein_beta_WD-40_rep.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS

 PR00320; GPROTEINBRPT.