CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024538
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myosin-7B 
Protein Synonyms/Alias
 Antigen MLAA-21; Myosin cardiac muscle beta chain; Myosin heavy chain 7B, cardiac muscle beta isoform; Slow A MYH14 
Gene Name
 MYH7B 
Gene Synonyms/Alias
 KIAA1512 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
237MEAFGNAKTLRNDNSubiquitination[1]
249DNSSRFGKFIRIHFGubiquitination[2]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Involved in muscle contraction. 
Sequence Annotation
 DOMAIN 87 766 Myosin head-like.
 DOMAIN 788 817 IQ.
 NP_BIND 177 184 ATP (By similarity).
 REGION 662 684 Actin-binding (By similarity).
 REGION 764 778 Actin-binding (By similarity).  
Keyword
 Actin-binding; Alternative splicing; ATP-binding; Coiled coil; Complete proteome; Membrane; Motor protein; Muscle protein; Myosin; Nucleotide-binding; Polymorphism; Reference proteome; Thick filament. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1941 AA 
Protein Sequence
MMDVSELGES ARYLRQGYQE MTKVHTIPWD GKKRVWVPDE QDAYVEAEVK SEATGGRVTV 60
ETKDQKVLMV REAELQPMNP PRFDLLEDMA MMTHLNEASV LHNLRQRYAR WMIYTYSGLF 120
CVTINPYKWL PVYTASVVAA YKGKRRSDSP PHIYAVADNA YNDMLRNRDN QSMLITGESG 180
AGKTVNTKRV IQYFAIVAAL GDGPGKKAQF LATKTGGTLE DQIIEANPAM EAFGNAKTLR 240
NDNSSRFGKF IRIHFGPSGK LASADIDSYL LEKSRVIFQL PGERSYHVYY QILSGRKPEL 300
QDMLLLSMNP YDYHFCSQGV ITVDNMNDGE ELIATDHAMD ILGFSVDEKC ACYKIVGALL 360
HFGNMKFKQK QREEQAEADG TESADKAAYL MGVSSGDLLK GLLHPRVRVG NEYVTKGQSV 420
EQVVFAVGAL AKATYDRLFR WLVSRINQTL DTKLPRQFFI GVLDIAGFEI FEFNSFEQLC 480
INFTNEKLQQ FFNQHMFVLE QEEYKREGID WVFIDFGLDL QPCIDLIEKP LGILSILEEE 540
CMFPKASDAS FRAKLYDNHA GKSPNFQQPR PDKKRKYQAH FEVVHYAGVV PYSIVGWLEK 600
NKDPLNETVV PIFQKSQNRL LATLYENYAG SCSTEPPKSG VKEKRKKAAS FQTVSQLHKE 660
NLNKLMTNLR ATQPHFVRCI VPNENKTPGV MDAFLVLHQL RCNGVLEGIR ICRQGFPNRL 720
LYTDFRQRYR ILNPSAIPDD TFMDSRKATE KLLGSLDLDH TQYQFGHTKV FFKAGLLGVL 780
EELRDQRLAK VLTLLQARSR GRLMRLEYQR LLGGRDALFT IQWNIRAFNA VKNWSWMKLF 840
FKMKPLLRSA QAEEELAALR AELRGLRGAL AAAEAKRQEL EETHVSITQE KNDLALQLQA 900
EQDNLADAEE RCHLLIKSKV QLEGKVKELS ERLEDEEEVN ADLAARRRKL EDECTELKKD 960
IDDLKLTLAK AEKEKQATEN KVKNLTEEMA ALDESVARLT KEKKALQEAH QQALGDLQAE 1020
EDRVSALTKA KLRLEQQVED LECSLEQEKK LRMDTERAKR KLEGDLKLTQ ESVADAAQDK 1080
QQLEEKLKKK DSELSQLSLR VEDEQLLGAQ MQKKIKELQA RAEELEEELE AERAARARVE 1140
KQRAEAAREL EELSERLEEA GGASAGQREG CRKREAELGR LRRELEEAAL RHEATVAALR 1200
RKQAEGAAEL GEQVDSLQRV RQKLEKEKSE LRMEVDDLAA NVETLTRAKA SAEKLCRTYE 1260
DQLSEAKIKV EELQRQLADA STQRGRLQTE SGELSRLLEE KECLISQLSR GKALAAQSLE 1320
ELRRQLEEES KAKSALAHAV QALRHDCDLL REQHEEEAEA QAELQRLLSK ANAEVAQWRS 1380
KYEADAIQRT EELEEAKKKL ALRLQEAEEG VEAANAKCSS LEKAKLRLQT ESEDVTLELE 1440
RATSAAAALD KKQRHLERAL EERRRQEEEM QRELEAAQRE SRGLGTELFR LRHGHEEALE 1500
ALETLKRENK NLQEEISDLT DQVSLSGKSI QELEKTKKAL EGEKSEIQAA LEEAEGALEL 1560
EETKTLRIQL ELSQVKAEVD RKLAEKDEEC ANLRRNHQRA VESLQASLDA ETRARNEALR 1620
LKKKMEGDLN DLELQLGHAT RQATEAQAAT RLMQAQLKEE QAGRDEEQRL AAELHEQAQA 1680
LERRASLLAA ELEELRAALE QGERSRRLAE QELLEATERL NLLHSQNTGL LNQKKKLEAD 1740
LAQLSGEVEE AAQERREAEE KAKKAITDAA MMAEELKKEQ DTSAHLERMK KTLEQTVREL 1800
QARLEEAEQA ALRGGKKQVQ KLEAKVRELE AELDAEQKKH AEALKGVRKH ERRVKELAYQ 1860
AEEDRKNLAR MQDLVDKLQS KVKSYKRQFE EAEQQANTNL AKYRKAQHEL DDAEERADMA 1920
ETQANKLRAR TRDALGPKHK E 1941 
Gene Ontology
 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0032982; C:myosin filament; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003774; F:motor activity; IEA:InterPro. 
Interpro
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027401; Myosin-like_IQ_dom.
 IPR015650; Myosin_1/23/4/7/8/13/15.
 IPR001609; Myosin_head_motor_dom.
 IPR004009; Myosin_N.
 IPR002928; Myosin_tail.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00063; Myosin_head
 PF02736; Myosin_N
 PF01576; Myosin_tail_1 
SMART
 SM00015; IQ
 SM00242; MYSc 
PROSITE
 PS50096; IQ 
PRINTS
 PR00193; MYOSINHEAVY.