CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036852
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 E3 ubiquitin-protein ligase TRIM33 
Protein Synonyms/Alias
  
Gene Name
 TRIM33 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
395SSGRTAEKTSLSFKSacetylation[1, 2, 3]
401EKTSLSFKSDQVKVKacetylation[1, 2, 3, 4]
425CSFSGGVKQEKTEDGacetylation[3]
493LSSLVNGKSPIRSLMacetylation[2]
583DNLQHSKKGKTAQGLacetylation[1, 2, 3, 4]
583DNLQHSKKGKTAQGLubiquitination[5]
585LQHSKKGKTAQGLSPacetylation[1, 2, 3, 4]
665ADVRLIFKNCERFNEubiquitination[5]
689DTQEINLKADSEVAQubiquitination[6]
Reference
 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Monoclonal antibody cocktail as an enrichment tool for acetylome analysis.
 Shaw PG, Chaerkady R, Zhang Z, Davidson NE, Pandey A.
 Anal Chem. 2011 May 15;83(10):3623-6. [PMID: 21466224]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [6] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 759 AA 
Protein Sequence
MKLLQQQNDI TGLSRQVKHV MNFTNWAIAS GSSTALLYSK RLITFQLRHI LKARCDPVPA 60
ANGAIRFHCD PTFWAKNVVN LGNLVIESKP APGYTPNVVV GQVPPGTNHI SKTPGQINLA 120
QLRLQHMQQQ VYAQKHQQLQ QMRMQQPPAP VPTTTTTTQQ HPRQAAPQML QQQPPRLISV 180
QTMQRGNMNC GAFQAHQMRL AQNAARIPGI PRHSGPQYSM MQPHLQRQHS NPGHAGPFPV 240
VSVHNTTINP TSPTTATMAN ANRGPTSPSV TAIELIPSVT NPENLPSLPD IPPIQANVVP 300
MMHSWYEFGA REKTQDQNVL EDAGSSSLDN LLSRYISGSH LPPQPTSTMN PSPGPSALSP 360
GSSGLSNSHT PVRPPSTSST GSRGSCGSSG RTAEKTSLSF KSDQVKVKQE PGTEDEICSF 420
SGGVKQEKTE DGRRSACMLS SPESSLTPPL STNLHLESEL DALASLENHV KIEPADMNES 480
CKQSGLSSLV NGKSPIRSLM HRSARIGGDG NNKDDDPNED WCAVCQNGGD LLCCEKCPKV 540
FHLTCHVPTL LSFPSGDWIC TFCRDIGKPE VEYDCDNLQH SKKGKTAQGL SPVDQRKCER 600
LLLYLYCHEL SIEFQEPVPA SIPNYYKIIK KPMDLSTVKK KLQKKHSQHY QIPDDFVADV 660
RLIFKNCERF NEMMKVVQVY ADTQEINLKA DSEVAQAGKA VALYFEDKLT EIYSDRTFAP 720
LPEFEQEEDD GEVTEDSDED FIQPRRKRLK SDERPVHIK 759 
Gene Ontology
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR001487; Bromodomain.
 IPR019786; Zinc_finger_PHD-type_CS.
 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR019787; Znf_PHD-finger.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF00439; Bromodomain
 PF00628; PHD 
SMART
 SM00297; BROMO
 SM00249; PHD 
PROSITE
 PS50014; BROMODOMAIN_2
 PS01359; ZF_PHD_1
 PS50016; ZF_PHD_2 
PRINTS