UniProt Accession

 J3QT22_HUMAN; J3QT22 

Genbank Protein ID

 AP000577; AP002392 

Genbank Nucleotide ID

  

Protein Name

 Protein phosphatase methylesterase 1 

Protein Synonyms/Alias

 PME-1 

Gene Name

 PPME1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
217	NAIEWSVKSGQIRNL	ubiquitination	[1]
295	LLFLQTKKDHPYTWR	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Demethylates proteins that have been reversibly carboxymethylated (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Hydrolase; Reference proteome; Serine esterase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 400 AA 

Protein Sequence

Gene Ontology

 GO:0004091; F:carboxylesterase activity; IEA:UniProtKB-KW. 

Interpro

 IPR016812; PPase_methylesterase_euk. 

Pfam

  

SMART

  

PROSITE

  

PRINTS