UniProt Accession

 HERP1_HUMAN; Q15011; E9PGD1; O60644; Q6IAN8; Q96D92 

Genbank Protein ID

 AB034989; D14695; AF055001; AF055003; AB034990; CR457116; AC012181; BC000086; BC008320; BC009739; BC032673 

Genbank Nucleotide ID

 BAB07891.1; BAA03521.1; AAC09355.1; AAC09357.1; BAB19010.1; CAG33397.1; AAH00086.1; AAH08320.1; AAH09739.1; AAH32673.1 

Protein Name

 Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein 

Protein Synonyms/Alias

 Methyl methanesulfonate (MMF)-inducible fragment protein 1 

Gene Name

 HERPUD1 

Gene Synonyms/Alias

 HERP; KIAA0025; MIF1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
99	KMPEINAKVAESTEE	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated beta-amyloid protein 40 generation. 

Sequence Annotation

 DOMAIN 10 72 Ubiquitin-like.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Endoplasmic reticulum; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Unfolded protein response. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 391 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; TAS:Reactome.
 GO:0006874; P:cellular calcium ion homeostasis; IEA:Compara.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0032092; P:positive regulation of protein binding; IEA:Compara.
 GO:0031396; P:regulation of protein ubiquitination; IEA:Compara.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:Compara. 

Interpro

 IPR000626; Ubiquitin.
 IPR019955; Ubiquitin_supergroup. 

Pfam

 PF00240; ubiquitin 

SMART

 SM00213; UBQ 

PROSITE

 PS50053; UBIQUITIN_2 

PRINTS