| Tag | Content |
|---|
| CPLM ID | CPLM-008448 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Excitatory amino acid transporter 3 |
Protein Synonyms/Alias | Excitatory amino-acid carrier 1; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1 |
Gene Name | Slc1a1 |
Gene Synonyms/Alias | Eaac1; Eaat3 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 467 | IVEKLSKKELEQMDV | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5. |
Sequence Annotation | CARBOHYD 128 128 N-linked (GlcNAc...) (Potential).
CARBOHYD 178 178 N-linked (GlcNAc...) (Potential).
CARBOHYD 194 194 N-linked (GlcNAc...) (Potential). |
Keyword | Complete proteome; Glycoprotein; Membrane; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 523 AA |
Protein Sequence | MGKPTSSGCD WRRFLRNHWL LLSTVAAVVL GIVLGVVVRG HSELSNLDKF YFAFPGEILM 60
RMLKLVILPL IVSSMITGVA ALDSNVSGKI GLRAVVYYFS TTVIAVILGI VLVVSIKPGV 120
TQKVNDINRT GKTPEVSTMD AMLDLIRNMF PENLVQACFQ QYKTKREEVK PVGDPGGNAT 180
EVSVTTAMTT MSENKTKEYK IVGLYSDGIN VLGLIIFCLV FGLVIGKMGE KGQILVDFFN 240
ALSDATMKIV QIIMCYMPIG ILFLIAGKII EVEDWEIFRK LGLYMATVLS GLAIHSLIVL 300
PLLYFIVVRK NPFRFALGMA QALLTALMIS SSSATLPVTF RCAEEKNQVD KRITRFVLPV 360
GATINMDGTA LYEAVAAVFI AQLNGLDLSI GQIVTISITA TAASIGAAGV PQAGLVTMVI 420
VLSAVGLPAE DVTLIIAVDW LLDRFRTMVN VLGDAFGTGI VEKLSKKELE QMDVSSEVNI 480
VNPFALEPTT LDNEDSDTKK SYVNGGFAVD KSDTISFTQT SQF 523 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IDA:MGI. GO:0016595; F:glutamate binding; IEA:Compara. GO:0015501; F:glutamate:sodium symporter activity; IDA:MGI. GO:0017153; F:sodium:dicarboxylate symporter activity; IEA:InterPro. GO:0070779; P:D-aspartate import; IEA:Compara. GO:0051938; P:L-glutamate import; IEA:Compara. GO:0051260; P:protein homooligomerization; IPI:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |