UniProt Accession

 TIMP4_HUMAN; Q99727; B2R7K6 

Genbank Protein ID

 U76456; AF057532; AF057528; AF057529; AF057530; AF057531; BT019627; AK313018; CH471055; BC010553 

Genbank Nucleotide ID

 AAB40391.1; AAC34422.1; AAC34422.1; AAC34422.1; AAC34422.1; AAC34422.1; AAV38433.1; BAG35853.1; EAW64122.1; AAH10553.1 

Protein Name

 Metalloproteinase inhibitor 4 

Protein Synonyms/Alias

 Tissue inhibitor of metalloproteinases 4; TIMP-4 

Gene Name

 TIMP4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
86	KMFKGFEKVKDVQYI	methylation	[1]

Reference

 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 

Functional Description

 Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP- 9. 

Sequence Annotation

 DOMAIN 30 156 NTR.
 REGION 30 34 Involved in metalloproteinase-binding (By
 REGION 99 100 Involved in metalloproteinase-binding (By
 METAL 30 30 Zinc; via amino nitrogen and carbonyl
 DISULFID 30 102 By similarity.
 DISULFID 32 131 By similarity.
 DISULFID 42 156 By similarity.
 DISULFID 158 205 By similarity.
 DISULFID 163 168 By similarity.
 DISULFID 176 197 By similarity.  

Keyword

 Complete proteome; Disulfide bond; Metal-binding; Metalloenzyme inhibitor; Metalloprotease inhibitor; Protease inhibitor; Reference proteome; Secreted; Signal; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 224 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; NAS:UniProtKB.
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0030017; C:sarcomere; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008191; F:metalloendopeptidase inhibitor activity; NAS:UniProtKB.
 GO:0007417; P:central nervous system development; IEA:Compara.
 GO:0042698; P:ovulation cycle; IEA:Compara.
 GO:0034097; P:response to cytokine stimulus; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
 GO:0043434; P:response to peptide hormone stimulus; IEA:Compara. 

Interpro

 IPR001134; Netrin_domain.
 IPR001820; Prot_inh_TIMP.
 IPR008993; TIMP-like_OB-fold.
 IPR015614; TIMP4.
 IPR027465; TIMP_C_dom. 

Pfam

 PF00965; TIMP 

SMART

 SM00206; NTR 

PROSITE

 PS50189; NTR
 PS00288; TIMP 

PRINTS