UniProt Accession

 SEPT5_MOUSE; Q9Z2Q6; B2RUC5; Q3UYG4; Q6PB74 

Genbank Protein ID

 AK134700; BC059848; BC141073; BC145331; AF033350 

Genbank Nucleotide ID

 BAE22248.1; AAH59848.1; AAI41074.1; AAI45332.1; AAC83974.1 

Protein Name

 Septin-5 

Protein Synonyms/Alias

 Cell division control-related protein 1; CDCrel-1; Peanut-like protein 1 

Gene Name

 Sept5 

Gene Synonyms/Alias

 Pnutl1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
71	LFLTDLYKDRKLLSA	ubiquitination	[1]
98	HTVDIEEKGVKLKLT	ubiquitination	[1]
181	FMKALHEKVNIVPLI	ubiquitination	[1]
190	NIVPLIAKADCLVPS	ubiquitination	[1]
239	KQQDRELKESAPFAV	ubiquitination	[1]
256	SNTVVEAKGQRVRGR	ubiquitination	[1]
296	RTHMHDLKDVTCDVH	acetylation	[2]
296	RTHMHDLKDVTCDVH	ubiquitination	[1]
318	CIQQMTSKLTQDSRM	ubiquitination	[1]
343	TPDAETEKLIRMKDE	acetylation	[3]
343	TPDAETEKLIRMKDE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Filament-forming cytoskeletal GTPase (By similarity). Involved in cytokinesis (Potential). May play a role in platelet secretion. 

Sequence Annotation

 NP_BIND 51 58 GTP (By similarity).
 NP_BIND 190 198 GTP (By similarity).
 BINDING 85 85 GTP (By similarity).
 BINDING 111 111 GTP; via amide nitrogen (By similarity).
 BINDING 248 248 GTP; via amide nitrogen and carbonyl
 BINDING 263 263 GTP (By similarity).
 MOD_RES 225 225 Phosphoserine.
 MOD_RES 327 327 Phosphoserine.
 MOD_RES 336 336 Phosphothreonine.  

Keyword

 Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; GTP-binding; Nucleotide-binding; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 369 AA 

Protein Sequence

Gene Ontology

 GO:0005938; C:cell cortex; IDA:MGI.
 GO:0005886; C:plasma membrane; ISS:UniProtKB.
 GO:0031105; C:septin complex; IEA:InterPro.
 GO:0008021; C:synaptic vesicle; ISS:UniProtKB.
 GO:0043195; C:terminal bouton; IDA:MGI.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0017157; P:regulation of exocytosis; ISS:UniProtKB. 

Interpro

 IPR000038; Cell_div_GTP-bd.
 IPR027417; P-loop_NTPase.
 IPR016491; Septin. 

Pfam

 PF00735; Septin 

SMART

  

PROSITE

  

PRINTS