CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014242
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Long-chain fatty acid transport protein 1 
Protein Synonyms/Alias
 FATP-1; Fatty acid transport protein 1; Solute carrier family 27 member 1 
Gene Name
 Slc27a1 
Gene Synonyms/Alias
 Fatp; Fatp1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
474VSDSATNKKIAHSVFubiquitination[1]
624RLFFLDLKQGRYVPLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FatP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane- associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. 
Sequence Annotation
 NP_BIND 246 257 AMP (Probable).
 REGION 191 475 Sufficient for oligomerization.  
Keyword
 Cell membrane; Complete proteome; Cytoplasm; Fatty acid metabolism; Ligase; Lipid metabolism; Lipid transport; Membrane; Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 646 AA 
Protein Sequence
MRAPGAGTAS VASLALLWFL GLPWTWSAAA AFCVYVGGGG WRFLRIVCKT ARRDLFGLSV 60
LIRVRLELRR HRRAGDTIPC IFQAVARRQP ERLALVDASS GICWTFAQLD TYSNAVANLF 120
RQLGFAPGDV VAVFLEGRPE FVGLWLGLAK AGVVAALLNV NLRREPLAFC LGTSAAKALI 180
YGGEMAAAVA EVSEQLGKSL LKFCSGDLGP ESILPDTQLL DPMLAEAPTT PLAQAPGKGM 240
DDRLFYIYTS GTTGLPKAAI VVHSRYYRIA AFGHHSYSMR AADVLYDCLP LYHSAGNIMG 300
VGQCVIYGLT VVLRKKFSAS RFWDDCVKYN CTVVQYIGEI CRYLLRQPVR DVEQRHRVRL 360
AVGNGLRPAI WEEFTQRFGV PQIGEFYGAT ECNCSIANMD GKVGSCGFNS RILTHVYPIR 420
LVKVNEDTME PLRDSEGLCI PCQPGEPGLL VGQINQQDPL RRFDGYVSDS ATNKKIAHSV 480
FRKGDSAYLS GDVLVMDELG YMYFRDRSGD TFRWRGENVS TTEVEAVLSR LLGQTDVAVY 540
GVAVPGVEGK AGMAAIADPH SQLDPNSMYQ ELQKVLASYA RPIFLRLLPQ VDTTGTFKIQ 600
KTRLQREGFD PRQTSDRLFF LDLKQGRYVP LDERVHARIC AGDFSL 646 
Gene Ontology
 GO:0031410; C:cytoplasmic vesicle; TAS:MGI.
 GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
 GO:0005783; C:endoplasmic reticulum; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0015245; F:fatty acid transporter activity; IDA:MGI.
 GO:0004467; F:long-chain fatty acid-CoA ligase activity; TAS:MGI.
 GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
 GO:0042803; F:protein homodimerization activity; IDA:MGI.
 GO:0031957; F:very long-chain fatty acid-CoA ligase activity; IDA:MGI.
 GO:0033211; P:adiponectin-mediated signaling pathway; IMP:MGI.
 GO:0032049; P:cardiolipin biosynthetic process; IEA:Compara.
 GO:0015909; P:long-chain fatty acid transport; IMP:MGI.
 GO:0001579; P:medium-chain fatty acid transport; IGI:MGI.
 GO:0071072; P:negative regulation of phospholipid biosynthetic process; IEA:Compara.
 GO:0006654; P:phosphatidic acid biosynthetic process; IEA:Compara.
 GO:0006656; P:phosphatidylcholine biosynthetic process; IEA:Compara.
 GO:0006646; P:phosphatidylethanolamine biosynthetic process; IEA:Compara.
 GO:0006661; P:phosphatidylinositol biosynthetic process; IEA:Compara.
 GO:0006659; P:phosphatidylserine biosynthetic process; IEA:Compara.
 GO:0031652; P:positive regulation of heat generation; IMP:MGI.
 GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IMP:MGI.
 GO:0009409; P:response to cold; IMP:MGI.
 GO:0032868; P:response to insulin stimulus; IMP:MGI. 
Interpro
 IPR020845; AMP-binding_CS.
 IPR000873; AMP-dep_Synth/Lig. 
Pfam
 PF00501; AMP-binding 
SMART
  
PROSITE
 PS00455; AMP_BINDING 
PRINTS