CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038657
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Unconventional myosin-XVIIIa 
Protein Synonyms/Alias
  
Gene Name
 Myo18a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
505APAVYSEKVMHMFKGubiquitination[1]
1012LLQDSQKKIISNLFLubiquitination[1]
2020KSWLSKNKGPSKAPSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Coiled coil; Complete proteome; Motor protein; Myosin; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2083 AA 
Protein Sequence
MFNLMKKDKD KDGGRKEKKE KKEKKERMSA AELRSLEEMS MRRGFFNLNR SSKRESKTRL 60
EISNPIPIKV ASGSDLHLTD IDSDSNRGSI ILDSGHLSTA SSSDDLKGEE GSFRGSVLQR 120
AAKFGSLAKQ NSQMIVKRFS FSQRSRDESA SETSTPSEHS AAPSPQVEVR TLEGQLMQHP 180
GLGIPRPGPR SRVPELVTKR FPADLRLPAL VPPPPPALRE LELQRRPTGD FGFSLRRTTM 240
LDRAPEGQAY RRVVHFAEPG AGTKDLALGL VPGDRLVEIN GQNVENKSRD EIVEMIRQSG 300
DSVRLKVQPI PELSELSRSW LRTGEGHRRE PADLDPEAAS PAYSQVGCSC PTQEPSAFSS 360
DNPPPPPCTW AGVCARASCW SAKTEEQIAA EEAWYETEKV WLVHRDGFSL ASQLKSEELS 420
LPEGKARVKL DHDGAILDVD EDDIEKANAP SCDRLEDLAS LVYLNESSVL HTLRQRYGAS 480
LLHTYAGPSL LVLSTRGAPA VYSEKVMHMF KGCRREDMAP HIYAVAQTAY RAMLMSRQDQ 540
SIVLLGSSGS GKTTSFQHLV QYLATIAGTS GTKVFSVEKW QALSTLLEAF GNSPTIMNGS 600
ATRFSQILSL DFDQAGQVAS ASIQTMLLEK LRVARRPASE ATFNVFYYLL ACGDATLRTE 660
LHLNHLAENN VFGIVPLSKP EEKQKAAQQF SKLQAAMKVL AISPEEQKTC WLILASIYHL 720
GAAGATKEAA EAGRKQFARH EWAQKAAYLL GCSLEELSSA IFKHQLKGGT LQRSTSFRQG 780
PEESGLGEGT KLSALECLEG MASGLYSELF TLLISLVNRA LKSSQHSLCS MMIVDTPGFQ 840
NPEWGGSARG ASFEELCHNY AQDRLQRLFH ERTFLQELER YKEDNIELAF DDLEPVADDS 900
VAAVDQASHL VRSLAHADEA RGLLWLLEEE ALVPGATEDA LLDRLFSYYG PQEGDKKGQS 960
PLLRSSKPRH FLLGHSHGTN WVEYNVAGWL NYTKQNPATQ NAPRLLQDSQ KKIISNLFLG 1020
RAGSATVLSG SIAGLEGGSQ LALRRATSMR KTFTTGMAAV KKKSLCIQIK LQVDALIDTI 1080
KRSKMHFVHC FLPVAEGWPG EPRSASSRRV SSSSELDLPP GDPCEAGLLQ LDVSLLRAQL 1140
RGSRLLDAMR MYRQGYPDHM VFSEFRRRFD VLAPHLTKKH GRNYIVVDEK RAVEELLESL 1200
DLEKSSCCLG LSRVFFRAGT LARLEEQRDE QTSRHLTLFQ AACRGYLARQ HFKKRKIQDL 1260
AIRCVQKNIK KNKGVKDWPW WKLFTTVRPL IQVQLSEEQI RNKDEEIQQL RSKLEKVEKE 1320
RNELRLSSDR LETRISELTS ELTDERNTGE SASQLLDAET AERLRTEKEM KELQTQYDAL 1380
KKQMEVMEME VMEARLIRAA EINGEVDDDD AGGEWRLKYE RAVREVDFTK KRLQQELEDK 1440
MEVEQQSRRQ LERRLGDLQA DSDESQRALQ QLKKKCQRLT AELQDTKLHL EGQQVRNHEL 1500
EKKQRRFDSE LSQAHEETQR EKLQREKLQR EKDMLLAEAF SLKQQMEEKD LDIAGFTQKV 1560
VSLEAELQDI SSQESKDEAS LAKVKKQLRD LEAKVKDQEE ELDEQAGSIQ MLEQAKLRLE 1620
MEMERMRQTH SKEMESRDEE VEEARQSCQK KLKQMEVQLE EEYEDKQKAL REKRELESKL 1680
STLSDQVNQR DFESEKRLRK DLKRTKALLA DAQIMLDHLK NNAPSKREIA QLKNQLEESE 1740
FTCAAAVKAR KAMEVEMEDL HLQIDDIAKA KTALEEQLSR LQREKNEIQN RLEEDQEDMN 1800
ELMKKHKAAV AQASRDMAQM NDLQAQIEES NKEKQELQEK LQALQSQVEF LEQSMVDKSL 1860
VSRQEAKIRE LETRLEFEKT QVKRLENLAS RLKETMEKLT EERDQRAAAE NREKEQNKRL 1920
QRQLRDTKEE MSELARKEAE ASRKKHELEM DLESLEAANQ SLQADLKLAF KRIGDLQAAI 1980
EDEMESDENE DLINSEGDSD VDSELEDRVD GVKSWLSKNK GPSKAPSDDG SLKSSSPTSH 2040
WKPLAPDPSD DEHDPVDSIS RPRFSHSYLS DSDTEAKLTE TSA 2083 
Gene Ontology
 GO:0005856; C:cytoskeleton; IDA:MGI.
 GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003774; F:motor activity; IEA:InterPro. 
Interpro
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027401; Myosin-like_IQ_dom.
 IPR001609; Myosin_head_motor_dom.
 IPR002928; Myosin_tail.
 IPR027417; P-loop_NTPase.
 IPR001478; PDZ. 
Pfam
 PF00063; Myosin_head
 PF01576; Myosin_tail_1
 PF00595; PDZ 
SMART
 SM00015; IQ
 SM00242; MYSc
 SM00228; PDZ 
PROSITE
 PS50096; IQ
 PS50106; PDZ 
PRINTS
 PR00193; MYOSINHEAVY.