UniProt Accession

 CHPT1_HUMAN; Q8WUD6; B3KQM2; Q7Z7H0; Q7Z7H1; Q7Z7H2; Q8IWQ4; Q8IWQ5; Q8WYI4; Q9NRQ6; Q9NRQ7; Q9Y6M6 

Genbank Protein ID

 AF195623; AF195624; AK075211; CH471054; BC020819; BC050429; AF047431; AF111803; AY280609; AY280610; AY294627; AY166717; AY166718 

Genbank Nucleotide ID

 AAF87947.1; AAF87948.1; BAG52084.1; EAW97675.1; AAH20819.1; AAH50429.1; AAD44019.1; AAL39005.1; AAP34412.1; AAP34413.1; AAP37157.1; AAN86122.1; AAN86123.1 

Protein Name

 Cholinephosphotransferase 1 

Protein Synonyms/Alias

 hCPT1; AAPT1-like protein; Diacylglycerol cholinephosphotransferase 1 

Gene Name

 CHPT1 

Gene Synonyms/Alias

 CPT1; MSTP022 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
399	QVQVLSSKSHQNNMD	ubiquitination	[1, 2]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Catalyzes phosphatidylcholine biosynthesis from CDP- choline. It thereby plays a central role in the formation and maintenance of vesicular membranes. 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Golgi apparatus; Lipid biosynthesis; Lipid metabolism; Magnesium; Manganese; Membrane; Metal-binding; Phospholipid biosynthesis; Phospholipid metabolism; Polymorphism; Reference proteome; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 406 AA 

Protein Sequence

Gene Ontology

 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0019992; F:diacylglycerol binding; NAS:UniProtKB.
 GO:0004142; F:diacylglycerol cholinephosphotransferase activity; IDA:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006663; P:platelet activating factor biosynthetic process; IDA:UniProtKB.
 GO:0001558; P:regulation of cell growth; NAS:UniProtKB. 

Interpro

 IPR000462; CDP-OH_P_trans.
 IPR014472; CHOPT. 

Pfam

 PF01066; CDP-OH_P_transf 

SMART

  

PROSITE

 PS00379; CDP_ALCOHOL_P_TRANSF 

PRINTS