CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037279
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein-tyrosine kinase 2-beta 
Protein Synonyms/Alias
  
Gene Name
 PTK2B 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
41QLTSQDAKPTCLAEFubiquitination[1]
310VASPECVKLGDFGLSacetylation[2]
327IEDEDYYKASVTRLPubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 596 AA 
Protein Sequence
MGRTALEQQS TLLLFQQGWN ITVDLVIGPK GIRQLTSQDA KPTCLAEFKQ IRSIRCLPLE 60
EGQAVLQLGI EGAPQALSIK TSSLAEAENM ADLIDGYCRL QGEHQGSLII HPRKDGEKRN 120
SLPQIPMLNL EARRSHLSES CSIESDIYAE IPDETLRRPG GPQYGIARED VVLNRILGEG 180
FFGEVYEGVY TNHKGEKINV AVKTCKKDCT LDNKEKFMSE AVIMKNLDHP HIVKLIGIIE 240
EEPTWIIMEL YPYGELGHYL ERNKNSLKVL TLVLYSLQIC KAMAYLESIN CVHRDIAVRN 300
ILVASPECVK LGDFGLSRYI EDEDYYKASV TRLPIKWMSP ESINFRRFTT ASDVWMFAVC 360
MWEILSFGKQ PFFWLENKDV IGVLEKGDRL PKPDLCPPVL YTLMTRCWDY DPSDRPRFTE 420
LVCSLSDVYQ MEKDIAMEQE RNARYRTPKI LEPTAFQEPP PKPSRPKYRP PPQTNLLAPK 480
LQFQEEDFIQ PSSREEAQQL WEAEKVKMRQ ILDKQQKQMV EDYQWLRQEE KSLDPMVYMN 540
DKSPLTPEKE VGYRECSRPS SGGFLLAPCA EPPSLPTAQG REQRSLSAFP AASAMI 596 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005856; C:cytoskeleton; IEA:InterPro.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. 
Interpro
 IPR000299; FERM_domain.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom. 
Pfam
 PF07714; Pkinase_Tyr 
SMART
 SM00219; TyrKc 
PROSITE
 PS50057; FERM_3
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR 
PRINTS
 PR00109; TYRKINASE.