UniProt Accession

 RNF13_HUMAN; O43567; Q6IBJ9 

Genbank Protein ID

 AF037204; AF070558; AK313304; AK090638; CR456804; AC069216; AC117395; CH471052; CH471052; CH471052; BC009803; BC009781 

Genbank Nucleotide ID

 AAC03769.1; AAC28641.1; BAG36109.1; BAG52202.1; CAG33085.1; EAW78859.1; EAW78861.1; EAW78863.1; AAH09803.1; AAH09781.1 

Protein Name

 E3 ubiquitin-protein ligase RNF13 

Protein Synonyms/Alias

 RING finger protein 13 

Gene Name

 RNF13 

Gene Synonyms/Alias

 RZF 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
107	LDCNFDIKVLNAQRA	ubiquitination	[1]
232	KLPVHKFKKGDEYDV	ubiquitination	[2]
233	LPVHKFKKGDEYDVC	ubiquitination	[1, 2]
273	CVDPWLTKTKKTCPV	ubiquitination	[1, 2]
276	PWLTKTKKTCPVCKQ	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. 

Sequence Annotation

 DOMAIN 65 160 PA.
 ZN_FING 240 282 RING-type; atypical.
 MOD_RES 292 292 Phosphoserine (By similarity).
 MOD_RES 294 294 Phosphoserine (By similarity).
 MOD_RES 296 296 Phosphothreonine (By similarity).
 MOD_RES 298 298 Phosphoserine (By similarity).
 MOD_RES 299 299 Phosphoserine (By similarity).
 CARBOHYD 88 88 N-linked (GlcNAc...).  

Keyword

 Complete proteome; Endoplasmic reticulum; Endosome; Glycoprotein; Golgi apparatus; Ligase; Lysosome; Membrane; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Signal; Transmembrane; Transmembrane helix; Ubl conjugation; Ubl conjugation pathway; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 381 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031902; C:late endosome membrane; ISS:UniProtKB.
 GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
 GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
 GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0051865; P:protein autoubiquitination; ISS:UniProtKB. 

Interpro

 IPR003137; Protease-assoc_domain.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 

Pfam

 PF02225; PA
 PF13639; zf-RING_2 

SMART

 SM00184; RING 

PROSITE

 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 

PRINTS