CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008888
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 FAS-associated factor 1 
Protein Synonyms/Alias
  
Gene Name
 Faf1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
138ELQIPVPKMLLKGWKubiquitination[1]
142PVPKMLLKGWKTGDVubiquitination[1]
145KMLLKGWKTGDVEDSubiquitination[1]
156VEDSTVLKSLHLPKNubiquitination[1]
220SSTVQEVKRNVYDLTubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Potentiates but cannot initiate FAS-induced apoptosis. 
Sequence Annotation
 DOMAIN 1 57 UBA.
 DOMAIN 568 645 UBX.
 MOD_RES 269 269 Phosphoserine.
 MOD_RES 319 319 Phosphoserine (By similarity).
 MOD_RES 579 579 Phosphothreonine.  
Keyword
 Apoptosis; Complete proteome; Nucleus; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 649 AA 
Protein Sequence
MASNMDREMI LADFQACTGI ENIDEAITLL EQNNWDLVAA INGVIPQENG ILQSDFGGET 60
MPGPTFDPAS HPAPASTPSS SAFRPVMPSR QIVERQPRML DFRVEYRDRN VDVVLEDSCT 120
VGEIKQILEN ELQIPVPKML LKGWKTGDVE DSTVLKSLHL PKNNSLYVLT PDLPPPSSSS 180
HAGALQESLN QNFMLIITHR EVQREYNLNF SGSSTVQEVK RNVYDLTSIP VRHQLWEGWP 240
ASATDDSMCL AESGLSYPCH RLTVGRRTSP VQTREQSEEQ STDVHMVSDS DGDDFEDASE 300
FGVDDGEVFG MASSTLRKSP MMPENAENEG DALLQFTAEF SSRYGDCHPV FFIGSLEAAF 360
QEAFYVKARD RKLLAIYLHH DESVLTNVFC SQMLCAESIV SYLSQNFITW AWDLTKDTNR 420
ARFLTMCNRH FGSVIAQTIR TQKTDQFPLF LIIMGKRSSN EVLNVIQGNT TVDELMMRLM 480
AAMEIFSAQQ QEDIKDEDER EARENVKREQ DEAYRLSLEA DRAKREAHER EMAEQFRLEQ 540
IRKEQEEERE AIRLSLEQAL PPEPKEENAE PVSKLRIRTP SGEFLERRFL ASNKLQIVFD 600
FVASKGFPWD EFKLLSTFPR RDVTQLDPNK SLLEVNLFPQ ETLFLQAKE 649 
Gene Ontology
 GO:0034098; C:Cdc48p-Npl4p-Ufd1p AAA ATPase complex; IEA:Compara.
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0005635; C:nuclear envelope; IDA:MGI.
 GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
 GO:0031072; F:heat shock protein binding; ISS:UniProtKB.
 GO:0019901; F:protein kinase binding; ISS:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0008219; P:cell death; ISS:UniProtKB.
 GO:0007253; P:cytoplasmic sequestering of NF-kappaB; ISS:UniProtKB.
 GO:0043065; P:positive regulation of apoptotic process; IDA:MGI.
 GO:0031334; P:positive regulation of protein complex assembly; ISS:UniProtKB.
 GO:0030155; P:regulation of cell adhesion; IMP:MGI.
 GO:0042176; P:regulation of protein catabolic process; ISS:UniProtKB. 
Interpro
 IPR006577; UAS.
 IPR001012; UBX. 
Pfam
 PF00789; UBX 
SMART
 SM00594; UAS
 SM00166; UBX 
PROSITE
 PS50030; UBA
 PS50033; UBX 
PRINTS