Tag | Content |
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CPLM ID | CPLM-014319 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Plastin-2 |
Protein Synonyms/Alias | 65 kDa macrophage protein; L-plastin; Lymphocyte cytosolic protein 1; LCP-1; pp65 |
Gene Name | Lcp1 |
Gene Synonyms/Alias | Pls2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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263 | ESLEDLMKLSPEELL | ubiquitination | [1] | 297 | STDIKDSKAYYHLLE | ubiquitination | [1] | 530 | NWVNTTLKEAQKSSS | ubiquitination | [1] | 584 | EEKLNNAKYAISMAR | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69 (By similarity). |
Sequence Annotation | DOMAIN 9 44 EF-hand 1. DOMAIN 49 84 EF-hand 2. DOMAIN 106 379 Actin-binding 1. DOMAIN 120 236 CH 1. DOMAIN 264 375 CH 2. DOMAIN 380 624 Actin-binding 2. DOMAIN 394 503 CH 3. DOMAIN 515 624 CH 4. MOD_RES 2 2 N-acetylalanine (By similarity). MOD_RES 5 5 Phosphoserine. MOD_RES 7 7 Phosphoserine. MOD_RES 28 28 Phosphotyrosine (By similarity). MOD_RES 30 30 Phosphoserine (By similarity). MOD_RES 76 76 N6-acetyllysine (By similarity). MOD_RES 88 88 N6-acetyllysine (By similarity). MOD_RES 124 124 Phosphotyrosine (By similarity). MOD_RES 257 257 Phosphoserine (By similarity). MOD_RES 294 294 N6-acetyllysine (By similarity). MOD_RES 297 297 N6-acetyllysine (By similarity). MOD_RES 323 323 Phosphoserine (By similarity). MOD_RES 361 361 N6-acetyllysine (By similarity). MOD_RES 472 472 N6-acetyllysine (By similarity). MOD_RES 542 542 N6-acetyllysine (By similarity). MOD_RES 579 579 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Actin-binding; Calcium; Cell junction; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Membrane; Metal-binding; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 627 AA |
Protein Sequence | MARGSVSDEE MMELREAFAK VDTDGNGYIS CNELNDLFKA ACLPLPGYRV REITENLMAT 60 GDLDQDGKIS FDEFIKVFHG LKSTEVAKTF RKAINKKEGI CAIGGTSEQS SVGTQHSYSE 120 EEKYAFVNWI NKALENDPDC RHVIPMNPNT DDLFNAVGDG IVLCKMINLS VPDTIDERTI 180 NKKKLTPFTI QENLNLALNS ASAIGCHVVN IGAEDLKEGK PYLVLGLLWQ VIKIGLFADI 240 ELSRNEALIA LLREGESLED LMKLSPEELL LRWANYHLEN AGCTKITNFS TDIKDSKAYY 300 HLLEQVAPKG DEEGIPAVVI DMSGLREKDD IQRAECMLQQ AERLGCRQFV TATDVVRGNP 360 KLNLAFIANL FNKYPALHKP ENQDIDWGAL EGETREERTF RNWMNSLGVN PRVNHLYSDL 420 SDALVIFQLY EKIKVPVDWN RVNKPPYPKL GGNMKKLENC NYAVDLGKNQ AKFSLVGIAG 480 QDLNEGNRTL TLALVWQLMR RYTLNILEDI GGGQKVNDDI IVNWVNTTLK EAQKSSSIAS 540 FKDPKISTSL PVLDLIDAIQ PGSINYDLLK TENLDDEEKL NNAKYAISMA RKIGARVYAL 600 PEDLVEVNPK MVMTVFACLM GKGMKRV 627 |
Gene Ontology | GO:0005884; C:actin filament; IDA:MGI. GO:0030054; C:cell junction; IEA:UniProtKB-SubCell. GO:0005829; C:cytosol; ISS:UniProtKB. GO:0001891; C:phagocytic cup; IDA:MGI. GO:0001726; C:ruffle; IDA:MGI. GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell. GO:0051015; F:actin filament binding; IDA:MGI. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0051017; P:actin filament bundle assembly; IDA:MGI. GO:0031100; P:organ regeneration; IEA:Compara. GO:0033157; P:regulation of intracellular protein transport; ISS:UniProtKB. GO:0002286; P:T cell activation involved in immune response; ISS:UniProtKB. |
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