UniProt Accession

 CLPP_MOUSE; O88696; Q3TI13 

Genbank Protein ID

 AJ005253; AJ012249; AJ012250; AJ012251; AJ012252; AJ012253; AK004024; AK145765; AK168053; BC001998 

Genbank Nucleotide ID

 CAA06443.1; CAA09966.1; CAA09966.1; CAA09966.1; CAA09966.1; CAA09966.1; BAB23132.1; BAE26636.1; BAE40033.1; AAH01998.1 

Protein Name

 Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial 

Protein Synonyms/Alias

 Endopeptidase Clp 

Gene Name

 Clpp 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
196	IQAEEIMKLKKQLYN	acetylation	[1]
196	IQAEEIMKLKKQLYN	succinylation	[1]
199	EEIMKLKKQLYNIYA	acetylation	[1]
199	EEIMKLKKQLYNIYA	succinylation	[1]
207	QLYNIYAKHTKQSLQ	acetylation	[2, 3]
210	NIYAKHTKQSLQVIE	acetylation	[2]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753] 

Functional Description

 Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. 

Sequence Annotation

 ACT_SITE 149 149 Probable.
 ACT_SITE 174 174 Probable.
 MOD_RES 207 207 N6-acetyllysine (By similarity).
 MOD_RES 272 272 Phosphothreonine (By similarity).  

Keyword

 Acetylation; ATP-binding; Complete proteome; Hydrolase; Mitochondrion; Nucleotide-binding; Phosphoprotein; Protease; Reference proteome; Serine protease; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 272 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
 GO:0006515; P:misfolded or incompletely synthesized protein catabolic process; ISA:MGI. 

Interpro

 IPR001907; ClpP.
 IPR023562; ClpP/TepA.
 IPR018215; ClpP_AS. 

Pfam

 PF00574; CLP_protease 

SMART

  

PROSITE

 PS00382; CLP_PROTEASE_HIS
 PS00381; CLP_PROTEASE_SER 

PRINTS

 PR00127; CLPPROTEASEP.