CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030081
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Metabotropic glutamate receptor subtype 5b 
Protein Synonyms/Alias
  
Gene Name
 Grm5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
827KVYIILAKPERNVRSubiquitination[1]
921VTWAQNEKSTRGQHLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Cell membrane; G-protein coupled receptor; Membrane; Receptor; Transducer; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1203 AA 
Protein Sequence
MVLLLILSVL LLKEDVRGSA QSSERRVVAH MPGDIIIGAL FSVHHQPTVD KVHERKCGAV 60
REQYGIQRVE AMLHTLERIN SDPTLLPNIT LGCEIRDSCW HSAVALEQSI EFIRDSLISS 120
EEEEGLVRCV DGSSSFRSKK PIVGVIGPGS SSVAIQVQNL LQLFNIPQIA YSATSMDLSD 180
KTLFKYFMRV VPSDAQQARA MVDIVKRYNW TYVSAVHTEG NYGESGMEAF KDMSAKEGIC 240
IAHSYKIYSN AGEQSFDKLL KKLRSHLPKA RVVACFCEGM TVRGLLMAMR RLGLAGEFLL 300
LGSDGWADRY DVTDGYQREA VGGITIKLQS PDVKWFDDYY LKLRPETNLR NPWFQEFWQH 360
RFQCRLEGFA QENSKYNKTC NSSLTLRTHH VQDSKMGFVI NAIYSMAYGL HNMQMSLCPG 420
YAGLCDAMKP IDGRKLLDSL MKTNFTGVSG DMILFDENGD SPGRYEIMNF KEMGKDYFDY 480
INVGSWDNGE LKMDDDEVWS KKNNIIRSVC SEPCEKGQIK VIRKGEVSCC WTCTPCKENE 540
YVFDEYTCKA CQLGSWPTDD LTGCDLIPVQ YLRWGDPEPI AAVVFACLGL LATLFVTVIF 600
IIYRDTPVVK SSSRELCYII LAGICLGYLC TFCLIAKPKQ IYCYLQRIGI GLSPAMSYSA 660
LVTKTNRIAR ILAGSKKKIC TKKPRFMSAC AQLVIAFILI CIQLGIIVAL FIMEPPDIMH 720
DYPSIREVYL ICNTTNLGVV TPLGYNGLLI LSCTFYAFKT RNVPANFNEA KYIAFTMYTT 780
CIIWLAFVPI YFGSNYKIIT MCFSVSLSAT VALGCMFVPK VYIILAKPER NVRSAFTTST 840
VVRMHVGDGK SSSAASRSSS LVNLWKRRGS SGETLRYKDR RLAQHKSEIE CFTPKGSMGN 900
GGRATMSSSN GKSVTWAQNE KSTRGQHLWQ RLSVHINKKE NPNQTAVIKP FPKSTESRGQ 960
GAGAGGGSGP GAAGAGSAGC TATGGPEPPD AGPKALYDVA EAEERFPAAA RPRSPSPIST 1020
LSHLAGSAGR TDDDAPSLHS ETAARSSSSQ GSLMEQISSV VTRFTANITE LNSMMLSTAA 1080
APGPPGTPIC SSYLIPKEIQ LPTTMTTFAE IQPLPAIEVT GGAQPATGPS PAQETPAGAE 1140
AAPGKPDLEE LVALTPPSPF RDSVDSGSTT PNSPVSESAL CIPSSPKYDT LIIRDYTQSS 1200
SSL 1203 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0043198; C:dendritic shaft; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0014069; C:postsynaptic density; IEA:Compara.
 GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
 GO:0001639; F:PLC activating G-protein coupled glutamate receptor activity; TAS:MGI.
 GO:0000185; P:activation of MAPKKK activity; IEA:Compara.
 GO:0002029; P:desensitization of G-protein coupled receptor protein signaling pathway; IEA:Compara.
 GO:0007612; P:learning; IMP:MGI.
 GO:0007626; P:locomotory behavior; IMP:MGI.
 GO:0040013; P:negative regulation of locomotion; IEA:Compara.
 GO:0048170; P:positive regulation of long-term neuronal synaptic plasticity; IEA:Compara.
 GO:0007205; P:protein kinase C-activating G-protein coupled receptor signaling pathway; IEA:Compara.
 GO:0006468; P:protein phosphorylation; IEA:Compara.
 GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IMP:MGI.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0007268; P:synaptic transmission; IEA:Compara. 
Interpro
 IPR001828; ANF_lig-bd_rcpt.
 IPR000337; GPCR_3.
 IPR011500; GPCR_3_9-Cys_dom.
 IPR017978; GPCR_3_C.
 IPR017979; GPCR_3_CS.
 IPR000162; GPCR_3_mtglu_rcpt.
 IPR000202; GPCR_3_mtglu_rcpt_5.
 IPR019588; Metabotropic_Glu_rcpt_Homer-bd. 
Pfam
 PF00003; 7tm_3
 PF01094; ANF_receptor
 PF10606; GluR_Homer-bdg
 PF07562; NCD3G 
SMART
  
PROSITE
 PS00979; G_PROTEIN_RECEP_F3_1
 PS00980; G_PROTEIN_RECEP_F3_2
 PS00981; G_PROTEIN_RECEP_F3_3
 PS50259; G_PROTEIN_RECEP_F3_4 
PRINTS
 PR00248; GPCRMGR.
 PR01055; MTABOTROPC5R.
 PR00593; MTABOTROPICR.