UniProt Accession

 ACTA_HUMAN; P62736; B2R8A4; P03996; P04108; Q6FI19 

Genbank Protein ID

 X13839; J05192; AY692464; CR536518; AK313294; AL157394; CH471066; BC017554; BC093052; K01741; K01742; K01743; M33216 

Genbank Nucleotide ID

 CAA32064.1; AAA51577.1; AAW29811.1; CAG38756.1; BAG36101.1; CAI13864.1; EAW50153.1; AAH17554.1; AAH93052.1; AAA60560.1 

Protein Name

 Actin, aortic smooth muscle 

Protein Synonyms/Alias

 Alpha-actin-2; Cell growth-inhibiting gene 46 protein 

Gene Name

 ACTA2 

Gene Synonyms/Alias

 ACTSA; ACTVS; GIG46 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
52	VMVGMGQKDSYVGDE	ubiquitination	[1]
63	VGDEAQSKRGILTLK	ubiquitination	[1]
70	KRGILTLKYPIEHGI	acetylation	[2]
70	KRGILTLKYPIEHGI	ubiquitination	[1, 3]
115	TEAPLNPKANREKMT	ubiquitination	[1, 3]
193	DLTDYLMKILTERGY	ubiquitination	[4]
215	REIVRDIKEKLCYVA	ubiquitination	[1]
293	KCDIDIRKDLYANNV	ubiquitination	[3, 5, 6]
317	GIADRMQKEITALAP	ubiquitination	[1]
328	ALAPSTMKIKIIAPP	ubiquitination	[1, 4]
330	APSTMKIKIIAPPER	ubiquitination	[4]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling.
 Xu G, Paige JS, Jaffrey SR.
 Nat Biotechnol. 2010 Aug;28(8):868-73. [PMID: 20639865]
 [5] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [6] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. 

Sequence Annotation

 MOD_RES 3 3 N-acetylglutamate (By similarity).
 MOD_RES 46 46 Methionine sulfoxide (By similarity).
 MOD_RES 75 75 Tele-methylhistidine (By similarity).  

Keyword

 Acetylation; Aortic aneurysm; ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; Disease mutation; Methylation; Muscle protein; Nucleotide-binding; Oxidation; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 377 AA 

Protein Sequence

Gene Ontology

 GO:0015629; C:actin cytoskeleton; IEA:Compara.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0043234; C:protein complex; IDA:MGI.
 GO:0030485; C:smooth muscle contractile fiber; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0072144; P:glomerular mesangial cell development; IEP:UniProtKB.
 GO:0006936; P:muscle contraction; TAS:Reactome.
 GO:0008217; P:regulation of blood pressure; IEA:Compara.
 GO:0009615; P:response to virus; IEP:UniProtKB.
 GO:0014829; P:vascular smooth muscle contraction; IEA:Compara. 

Interpro

 IPR004000; Actin-related.
 IPR020902; Actin/actin-like_CS.
 IPR004001; Actin_CS. 

Pfam

 PF00022; Actin 

SMART

 SM00268; ACTIN 

PROSITE

 PS00406; ACTINS_1
 PS00432; ACTINS_2
 PS01132; ACTINS_ACT_LIKE 

PRINTS

 PR00190; ACTIN.