CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037131
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Piezo-type mechanosensitive ion channel component 1 
Protein Synonyms/Alias
  
Gene Name
 PIEZO1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
181NFQRDLAKGGTVEYAubiquitination[1, 2]
240GPEANPVKQLQPNEEubiquitination[1, 2, 3, 4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 373 AA 
Protein Sequence
MKICPFSSKS SIVLALKFRS LIHFEKYPQP KGQKKKKIVK YGMGGLIILF LIAIIWFPLL 60
FMSLVRSVVG VVNQPIDVTV TLKLGGYEPL FTMSAQQPSI IPFTAQAYEE LSRQFDPQPL 120
AMQFISQYSP EDIVTAQIEG SSGALWRISP PSRAQMKREL YNGTADITLR FTWNFQRDLA 180
KGGTVEYANE KHMLALAPNS TARRQLASLL EGTSDQSVVI PNLFPKYIRA PNGPEANPVK 240
QLQPNEEADY LGVRIQLRRE QGAGATGFLE WWVIELQECR TDCNLLPMVI FSDKHHGAVR 300
VHRAGHRQVR ARILQRDLAL HYVRGAAVRG PHPQALPGHL PGAGDSGAGA GGGVVRQAHL 360
PLPLTGDHDQ VDS 373 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0008381; F:mechanically-gated ion channel activity; IEA:InterPro. 
Interpro
 IPR027272; Piezo. 
Pfam
 PF12166; DUF3595 
SMART
  
PROSITE
  
PRINTS