UniProt Accession

 C9J858_HUMAN; C9J858 

Genbank Protein ID

 AL096712 

Genbank Nucleotide ID

  

Protein Name

 E3 ubiquitin-protein ligase RNF8 

Protein Synonyms/Alias

  

Gene Name

 RNF8 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
23	QWTIMDNKSLNGVWL	ubiquitination	[1]
135	QPVKSQGKGEVASTP	ubiquitination	[1]
157	LTALEPSKTTGAPIY	ubiquitination	[1]
178	TEVHHEQKASNSSAS	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 205 AA 

Protein Sequence

Gene Ontology

 GO:0000781; C:chromosome, telomeric region; IEA:Compara.
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0004842; F:ubiquitin-protein ligase activity; IEA:Compara.
 GO:0051301; P:cell division; IEA:InterPro.
 GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:Compara.
 GO:0043486; P:histone exchange; IEA:Compara.
 GO:0033522; P:histone H2A ubiquitination; IEA:Compara.
 GO:0033523; P:histone H2B ubiquitination; IEA:Compara.
 GO:0045190; P:isotype switching; IEA:Compara.
 GO:0007286; P:spermatid development; IEA:Compara. 

Interpro

 IPR017335; E3_Ub_ligase_RNF8.
 IPR000253; FHA_dom.
 IPR008984; SMAD_FHA_domain. 

Pfam

 PF00498; FHA 

SMART

  

PROSITE

 PS50006; FHA_DOMAIN 

PRINTS