CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015745
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Basic leucine zipper and W2 domain-containing protein 1 
Protein Synonyms/Alias
 Protein Orf 
Gene Name
 BZW1 
Gene Synonyms/Alias
 BZAP45; KIAA0005 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
37VSFMNNQKQQKPTLSubiquitination[1]
40MNNQKQQKPTLSGQRubiquitination[1]
92FLDASGAKLDYRRYAubiquitination[1]
229FKSWINEKDINAVAAubiquitination[1]
255MELFPANKQSVEHFTubiquitination[1]
271YFTEAGLKELSEYVRubiquitination[1]
287QQTIGARKELQKELQubiquitination[1]
291GARKELQKELQEQMSubiquitination[1]
304MSRGDPFKDIILYVKubiquitination[1]
422DAHVAKGKSVFLEQMubiquitination[1]
431VFLEQMKKFVEWLKNubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Enhances histone H4 gene transcription but does not seem to bind DNA directly. 
Sequence Annotation
 DOMAIN 247 414 W2.
 MOD_RES 411 411 Phosphoserine.
 MOD_RES 413 413 Phosphoserine.  
Keyword
 Activator; Alternative splicing; Complete proteome; Direct protein sequencing; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 419 AA 
Protein Sequence
MYGAPGAPAQ SASVTVVRSL RRPPPQATGV SFMNNQKQQK PTLSGQRFKT RKRDEKERFD 60
PTQFQDCIIQ GLTETGTDLE AVAKFLDASG AKLDYRRYAE TLFDILVAGG MLAPGGTLAD 120
DMMRTDVCVF AAQEDLETMQ AFAQVFNKLI RRYKYLEKGF EDEVKKLLLF LKGFSESERN 180
KLAMLTGVLL ANGTLNASIL NSLYNENLVK EGVSAAFAVK LFKSWINEKD INAVAASLRK 240
VSMDNRLMEL FPANKQSVEH FTKYFTEAGL KELSEYVRNQ QTIGARKELQ KELQEQMSRG 300
DPFKDIILYV KEEMKKNNIP EPVVIGIVWS SVMSTVEWNK KEELVAEQAI KHLKQYSPLL 360
AAFTTQGQSE LTLLLKIQEY CYDNIHFMKA FQKIVVLFYK AEVLSEEPIL KWYKDAHVAK 420
GKSVFLEQMK KFVEWLKNAE EESESEAEEG D 451 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR016024; ARM-type_fold.
 IPR016021; MIF4-like_typ_1/2/3.
 IPR003307; W2_domain. 
Pfam
 PF02020; W2 
SMART
 SM00515; eIF5C 
PROSITE
 PS51363; W2 
PRINTS