CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027387
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Heat shock protein 86 
Protein Synonyms/Alias
  
Gene Name
 PF07_0029 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Plasmodium falciparum (isolate 3D7) 
NCBI Taxa ID
 36329 
Lysine Modification
Position
Peptide
Type
References
178TKIILHLKEDQLEYLacetylation[1]
188QLEYLEEKRIKDLVKacetylation[1]
289EELENAEKKKKEKRKacetylation[1]
565KKLKCCTKEGLDIDDacetylation[1]
601IKDVLHEKVEKVVVGacetylation[1]
Reference
 [1] Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development.
 Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L.
 Mol Microbiol. 2013 Aug;89(4):660-75. [PMID: 23796209] 
Functional Description
  
Sequence Annotation
 REGION 85 87 Sulfate 3 binding.
 BINDING 44 44 Sulfate 2.
 BINDING 152 152 Sulfate 1; via carbonyl oxygen.  
Keyword
 3D-structure; Complete proteome; Reference proteome; Stress response. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 745 AA 
Protein Sequence
MSTETFAFNA DIRQLMSLII NTFYSNKEIF LRELISNASD ALDKIRYESI TDTQKLSAEP 60
EFFIRIIPDK TNNTLTIEDS GIGMTKNDLI NNLGTIARSG TKAFMEAIQA SGDISMIGQF 120
GVGFYSAYLV ADHVVVISKN NDDEQYVWES AAGGSFTVTK DETNEKLGRG TKIILHLKED 180
QLEYLEEKRI KDLVKKHSEF ISFPIKLYCE RQNEKEITAS EEEEGEGEGE REGEEEEEKK 240
KKTGEDKNAD ESKEENEDEE KKEDNEEDDN KTDHPKVEDV TEELENAEKK KKEKRKKKIH 300
TVEHEWEELN KQKPLWMRKP EEVTNEEYAS FYKSLTNDWE DHLAVKHFSV EGQLEFKALL 360
FIPKRAPFDM FENRKKRNNI KLYVRRVFIM DDCEEIIPEW LNFVKGVVDS EDLPLNISRE 420
SLQQNKILKV IKKNLIKKCL DMFSELAENK ENYKKFYEQF SKNLKLGIHE DNANRTKITE 480
LLRFQTSKSG DEMIGLKEYV DRMKENQKDI YYITGESINA VSNSPFLEAL TKKGFEVIYM 540
VDPIDEYAVQ QLKDFDGKKL KCCTKEGLDI DDSEEAKKDF ETLKAEYEGL CKVIKDVLHE 600
KVEKVVVGQR ITDSPCVLVT SEFGWSANME RIMKAQALRD NSMTSYMLSK KIMEINARHP 660
IISALKQKAD ADKSDKTVKD LIWLLFDTSL LTSGFALEEP TTFSKRIHRM IKLGLSIDEE 720
ENNDIDLPPL EETVDATDSK MEEVD 745 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0006457; P:protein folding; IEA:InterPro.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW. 
Interpro
 IPR003594; HATPase_ATP-bd.
 IPR019805; Heat_shock_protein_90_CS.
 IPR001404; Hsp90.
 IPR020575; Hsp90_N.
 IPR020568; Ribosomal_S5_D2-typ_fold. 
Pfam
 PF02518; HATPase_c
 PF00183; HSP90 
SMART
 SM00387; HATPase_c 
PROSITE
 PS00298; HSP90 
PRINTS
 PR00775; HEATSHOCK90.