UniProt Accession

 UHMK1_MOUSE; P97343; Q61775; Q9CYT1 

Genbank Protein ID

 AY180177; Y10725; BC058732; AK013347; X82320 

Genbank Nucleotide ID

 AAO13515.1; CAA71714.2; AAH58732.1; BAB28802.1; CAA57763.1 

Protein Name

 Serine/threonine-protein kinase Kist 

Protein Synonyms/Alias

 Kinase interacting with stathmin; PAM COOH-terminal interactor protein 2; P-CIP2; U2AF homology motif kinase 1 

Gene Name

 Uhmk1 

Gene Synonyms/Alias

 Kis; Kist 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
383	YANAGDSKAAQKLLT	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity). 

Sequence Annotation

 DOMAIN 23 303 Protein kinase.
 DOMAIN 323 405 RRM.
 NP_BIND 29 37 ATP (By similarity).
 ACT_SITE 158 158 Proton acceptor (By similarity).
 BINDING 54 54 ATP (By similarity).  

Keyword

 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Nucleus; Reference proteome; RNA-binding; Serine/threonine-protein kinase; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 419 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IDA:BHF-UCL.
 GO:0032839; C:dendrite cytoplasm; IDA:BHF-UCL.
 GO:0071598; C:neuronal ribonucleoprotein granule; IDA:BHF-UCL.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
 GO:0043021; F:ribonucleoprotein complex binding; IDA:BHF-UCL.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0007050; P:cell cycle arrest; ISS:HGNC.
 GO:0031175; P:neuron projection development; IMP:BHF-UCL.
 GO:0018105; P:peptidyl-serine phosphorylation; ISS:UniProtKB.
 GO:0045948; P:positive regulation of translational initiation; IMP:BHF-UCL.
 GO:0046777; P:protein autophosphorylation; ISS:HGNC.
 GO:0046825; P:regulation of protein export from nucleus; ISS:HGNC. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000719; Prot_kinase_cat_dom.
 IPR000504; RRM_dom. 

Pfam

 PF00069; Pkinase 

SMART

 SM00360; RRM 

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST
 PS50102; RRM 

PRINTS