UniProt Accession

 CDC23_HUMAN; Q9UJX2; A8K6E5; B4E3A2; B7WP05; D3DQB7; O75433; Q53FN2; Q9BS73 

Genbank Protein ID

 AB011472; AK291610; AK304635; AY603103; AK223250; AC106752; CH471062; CH471062; CH471062; BC005258; BC010944; BC017713; AF053977; AF191341; BT009810 

Genbank Nucleotide ID

 BAA75628.1; BAF84299.1; BAG65414.1; AAS99353.1; BAD96970.1; EAW62155.1; EAW62154.1; EAW62156.1; AAH05258.1; AAH10944.1; AAH17713.1; AAC70920.1; AAF05755.1; AAP88812.1 

Protein Name

 Cell division cycle protein 23 homolog 

Protein Synonyms/Alias

 Anaphase-promoting complex subunit 8; APC8; Cyclosome subunit 8 

Gene Name

 CDC23 

Gene Synonyms/Alias

 ANAPC8 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
25	DSLGPLEKGQVKNEA	ubiquitination	[1]
335	LNQLVEAKKCYWRAY	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. 

Sequence Annotation

 REPEAT 83 116 TPR 1.
 REPEAT 169 202 TPR 2.
 REPEAT 228 261 TPR 3.
 REPEAT 263 296 TPR 4.
 REPEAT 331 364 TPR 5.
 REPEAT 366 398 TPR 6.
 REPEAT 400 432 TPR 7.
 REPEAT 433 466 TPR 8.
 REPEAT 468 500 TPR 9.
 MOD_RES 273 273 Phosphotyrosine.
 MOD_RES 467 467 N6-acetyllysine.
 MOD_RES 562 562 Phosphothreonine.
 MOD_RES 565 565 Phosphothreonine.
 MOD_RES 578 578 Phosphoserine.
 MOD_RES 582 582 Phosphothreonine.
 MOD_RES 588 588 Phosphoserine.
 MOD_RES 593 593 Phosphoserine.
 MOD_RES 596 596 Phosphothreonine.  

Keyword

 Acetylation; Alternative splicing; Cell cycle; Cell division; Complete proteome; Mitosis; Phosphoprotein; Polymorphism; Reference proteome; Repeat; TPR repeat; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 597 AA 

Protein Sequence

Gene Ontology

 GO:0005680; C:anaphase-promoting complex; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0004842; F:ubiquitin-protein ligase activity; TAS:UniProtKB.
 GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0000080; P:G1 phase of mitotic cell cycle; IDA:UniProtKB.
 GO:0007091; P:metaphase/anaphase transition of mitotic cell cycle; TAS:ProtInc.
 GO:0007080; P:mitotic metaphase plate congression; IDA:UniProtKB.
 GO:0007094; P:mitotic spindle assembly checkpoint; TAS:Reactome.
 GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.
 GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.
 GO:0070979; P:protein K11-linked ubiquitination; IDA:UniProtKB.
 GO:0007096; P:regulation of exit from mitosis; TAS:ProtInc. 

Interpro

 IPR007192; APC8.
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 

Pfam

 PF04049; APC8
 PF00515; TPR_1 

SMART

 SM00028; TPR 

PROSITE

 PS50005; TPR
 PS50293; TPR_REGION 

PRINTS