UniProt Accession

 ZNT1_MOUSE; Q60738 

Genbank Protein ID

 U17132; BC052166 

Genbank Nucleotide ID

 AAA79233.1; AAH52166.1 

Protein Name

 Zinc transporter 1 

Protein Synonyms/Alias

 ZnT-1; Solute carrier family 30 member 1 

Gene Name

 Slc30a1 

Gene Synonyms/Alias

 Znt1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
198	TSNSNGLKADQAEPE	ubiquitination	[1]
206	ADQAEPEKLRSDDPV	ubiquitination	[1]
396	ASYMQVAKTIKDVFH	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 May be involved in zinc transport out of the cell. Lethality of knockout early in gestation suggests a role of the protein in fetal zinc acquisition and retention. 

Sequence Annotation

 REGION 145 156 6 X 2 AA approximate repeats of H-G.
 MOD_RES 502 502 Phosphoserine (By similarity).
 CARBOHYD 294 294 N-linked (GlcNAc...) (Potential).  

Keyword

 Cell membrane; Complete proteome; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 503 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; ISO:MGI.
 GO:0030315; C:T-tubule; IEA:Compara.
 GO:0019855; F:calcium channel inhibitor activity; IDA:BHF-UCL.
 GO:0005385; F:zinc ion transmembrane transporter activity; ISO:MGI.
 GO:0070574; P:cadmium ion transmembrane transport; IEA:Compara.
 GO:0070509; P:calcium ion import; IEA:Compara.
 GO:0006874; P:cellular calcium ion homeostasis; IDA:BHF-UCL.
 GO:0006882; P:cellular zinc ion homeostasis; IDA:BHF-UCL.
 GO:0071585; P:detoxification of cadmium ion; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0090281; P:negative regulation of calcium ion import; IDA:BHF-UCL.
 GO:0046929; P:negative regulation of neurotransmitter secretion; IEA:Compara.
 GO:0071584; P:negative regulation of zinc ion transmembrane import; IDA:BHF-UCL. 

Interpro

 IPR002524; Cation_efflux.
 IPR027469; Cation_efflux_TMD. 

Pfam

 PF01545; Cation_efflux 

SMART

  

PROSITE

  

PRINTS