UniProt Accession

 VPS36_HUMAN; Q86VN1; A8K125; Q3ZCV7; Q5H9S1; Q5VXB6; Q9H8Z5; Q9Y3E3 

Genbank Protein ID

 AF151903; AK023182; AK289740; CR933653; AL359513; CH471274; BC037279; BC050439 

Genbank Nucleotide ID

 AAD34140.1; BAB14451.1; BAF82429.1; CAI45953.1; CAH71658.1; EAW55895.1; AAH37279.1; AAH50439.1 

Protein Name

 Vacuolar protein-sorting-associated protein 36 

Protein Synonyms/Alias

 ELL-associated protein of 45 kDa; ESCRT-II complex subunit VPS36 

Gene Name

 VPS36 

Gene Synonyms/Alias

 C13orf9; EAP45; CGI-145 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
44	PGPFQSSKNSYIKLS	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3. 

Sequence Annotation

 DOMAIN 1 88 GLUE N-terminal.
 DOMAIN 105 138 GLUE C-terminal.  

Keyword

 3D-structure; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Endosome; Lipid-binding; Membrane; Nucleus; Protein transport; Reference proteome; Transcription; Transcription regulation; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 386 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005768; C:endosome; IDA:UniProtKB.
 GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
 GO:0005764; C:lysosome; IEA:Compara.
 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:InterPro.
 GO:0016044; P:cellular membrane organization; TAS:Reactome.
 GO:0016197; P:endosomal transport; TAS:Reactome.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR007286; EAP30.
 IPR021648; VPS36_GLUE.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF04157; EAP30
 PF11605; Vps36_ESCRT-II 

SMART

  

PROSITE

 PS51495; GLUE 

PRINTS