CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015319
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 T-cell receptor-associated transmembrane adapter 1 
Protein Synonyms/Alias
 T-cell receptor-interacting molecule; TRIM; pp29/30 
Gene Name
 TRAT1 
Gene Synonyms/Alias
 TCRIM; HSPC062 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
92RPEKSVNKMQEATPSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells. 
Sequence Annotation
 REGION 79 82 Interaction with PIK3R1.
 MOD_RES 79 79 Phosphotyrosine (Probable).
 DISULFID 7 7 Interchain (Probable).  
Keyword
 Adaptive immunity; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Immunity; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 186 AA 
Protein Sequence
MSGISGCPFF LWGLLALLGL ALVISLIFNI SHYVEKQRQD KMYSYSSDHT RVDEYYIEDT 60
PIYGNLDDMI SEPMDENCYE QMKARPEKSV NKMQEATPSA QATNETQMCY ASLDHSVKGK 120
RRKPRKQNTH FSDKDGDEQL HAIDASVSKT TLVDSFSPES QAVEENIHDD PIRLFGLIRA 180
KREPIN 186 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0042101; C:T cell receptor complex; IDA:MGI.
 GO:0005068; F:transmembrane receptor protein tyrosine kinase adaptor activity; TAS:ProtInc.
 GO:0006968; P:cellular defense response; TAS:ProtInc.
 GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.
 GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0001920; P:negative regulation of receptor recycling; IDA:MGI.
 GO:0051051; P:negative regulation of transport; IDA:MGI.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
 GO:0048015; P:phosphatidylinositol-mediated signaling; TAS:Reactome.
 GO:0050850; P:positive regulation of calcium-mediated signaling; IDA:MGI.
 GO:0050862; P:positive regulation of T cell receptor signaling pathway; IDA:MGI.
 GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome. 
Interpro
 IPR020399; T-cell_rcpt-assoc_TM_adapter-1. 
Pfam
  
SMART
  
PROSITE
  
PRINTS