CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-045049
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Glucose-6-phosphate isomerase 
Protein Synonyms/Alias
  
Gene Name
 GPI 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
60GDMESNGKYITKSGTubiquitination[1, 2, 3, 4, 5]
64SNGKYITKSGTRVDHubiquitination[1, 6]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 120 AA 
Protein Sequence
MDQHFRTTPL EKNAPVLLAL LGIWYINCFG CETHAMLPYD QYLHRFAAYF QQGDMESNGK 60
YITKSGTRVD HQTGPIVWGE PGTNGQHAFY QLIHQGTKMI PCDFLIPVQT QHPIRKGLHH 120 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0004347; F:glucose-6-phosphate isomerase activity; IEA:Compara.
 GO:0016866; F:intramolecular transferase activity; IEA:Compara.
 GO:0048029; F:monosaccharide binding; IEA:Compara.
 GO:0046185; P:aldehyde catabolic process; IEA:Compara.
 GO:0006094; P:gluconeogenesis; IEA:InterPro.
 GO:0051156; P:glucose 6-phosphate metabolic process; IEA:Compara.
 GO:0006096; P:glycolysis; IEA:InterPro.
 GO:0007611; P:learning or memory; IEA:Compara.
 GO:0019242; P:methylglyoxal biosynthetic process; IEA:Compara.
 GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Compara. 
Interpro
 IPR001672; G6P_Isomerase. 
Pfam
 PF00342; PGI 
SMART
  
PROSITE
 PS51463; P_GLUCOSE_ISOMERASE_3 
PRINTS