CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015529
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 La-related protein 1 
Protein Synonyms/Alias
 La ribonucleoprotein domain family member 1 
Gene Name
 Larp1 
Gene Synonyms/Alias
 Kiaa0731; Larp 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
730PTDALANKLFGAPEPubiquitination[1]
994KLQEYLGKFRRLEDFubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
 DOMAIN 372 462 HTH La-type RNA-binding.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 68 68 Phosphoserine (By similarity).
 MOD_RES 81 81 Phosphoserine.
 MOD_RES 138 138 Phosphoserine (By similarity).
 MOD_RES 188 188 Phosphoserine (By similarity).
 MOD_RES 193 193 Phosphoserine (By similarity).
 MOD_RES 201 201 Phosphoserine.
 MOD_RES 299 299 Phosphoserine.
 MOD_RES 302 302 Phosphoserine.
 MOD_RES 351 351 Phosphothreonine (By similarity).
 MOD_RES 494 494 Phosphoserine (By similarity).
 MOD_RES 498 498 Phosphoserine (By similarity).
 MOD_RES 503 503 Phosphothreonine.
 MOD_RES 525 525 Phosphoserine.
 MOD_RES 604 604 Phosphoserine.
 MOD_RES 608 608 Phosphoserine.
 MOD_RES 626 626 Phosphothreonine (By similarity).
 MOD_RES 701 701 Phosphothreonine (By similarity).
 MOD_RES 743 743 Phosphoserine (By similarity).
 MOD_RES 751 751 Phosphoserine.
 MOD_RES 754 754 Phosphotyrosine (By similarity).
 MOD_RES 801 801 Phosphoserine (By similarity).
 MOD_RES 822 822 Phosphothreonine (By similarity).
 MOD_RES 828 828 Phosphoserine.
 MOD_RES 842 842 Phosphothreonine (By similarity).
 MOD_RES 845 845 Phosphoserine (By similarity).
 MOD_RES 869 869 N6-acetyllysine (By similarity).
 MOD_RES 994 994 N6-acetyllysine (By similarity).
 MOD_RES 1032 1032 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Phosphoprotein; Reference proteome; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1072 AA 
Protein Sequence
MATQVEPLLP AGAPLLQAEE HGLARKKPAP DAQAESGPGD GGGEPDGGVR RPRPACARPG 60
RDGAERESPR PPAAAEAPAG SDGEDGGRRD FVEAPPPKVN PWTKHAPPPA AVNGQPPPEP 120
SAPAKVVRAA APKPRKGSKV GDFGDAVNWP TPGEIAHKSV QPQSHKPQPA RKLPPKKDMK 180
EQEKGDGSDS KESPKTKSDE SGEEKNGDED CQRGGQKKKG NKHKWVPLQI DMKPEVPREK 240
LASRPTRPQE PRHTPAVRGE MKGSEPATYM PVSVAPPTPA WQPETKVEPA WHDQDETSSV 300
KSDGAGGARA SFRGRGRGRG RGRGRGRGGT RTHFDYQFGY RKFDGTEGPR THKYMNNITY 360
YFDNVSSNEI YSMDQELLKD YIKRQIEYYF SVDNLERDFF LRRKMDADGF LPITLIASFH 420
RVQALTTDIS LIFAALKDSK VVEMVEEKVR RREEPEKWPL PGPPIVDYSQ TDFSQLLNCP 480
EFVPRQHYQK ETESAPGSPR AVTPVPTKTE EVSNLKTLPK GLSASLPDLD SESWIEVKKR 540
PRPSPARPKK PEEPRFSHPT ALPQQLPSQQ LMSKDQDEQE ELDFLFDEEM EQMDGRKNTF 600
TAWSEEDSDY EIDDRDVNKI LIVTQTPPYM RRHPGGDRTG NHTSRAKMSA ELAKVINDGL 660
FYYEQDLWTE KFEPEYSQIK QEVENFKKVN MISREQFDTL TPEPPVDPNQ EVPPGPPRFQ 720
QVPTDALANK LFGAPEPSTI ARSLPTTVPE SPNYRNARTP RTPRTPQLKD SSQTPRFYPV 780
VKEGRTLDAK MPRKRKTRHS SNPPLESHVG WVMDSREHRP RTASISSSPS EGTPAVGSYG 840
CTPQSLPKFQ HPSHELLKEN GFTQHVYHKY RRRCLNERKR LGIGQSQEMN TLFRFWSFFL 900
RDHFNKKMYE EFKQLALEDA KEGYRYGLEC LFRYYSYGLE KKFRLDIFKD FQEETVKDYE 960
AGQLYGLEKF WAFLKYSKAK NLDIDPKLQE YLGKFRRLED FRVDPPMGEE GNHKRHPVVA 1020
GGSGEGRKRC PSQSSSRPAT GISQPPTTPT GQATREDAKW TSQHSDTLTL RK 1072 
Gene Ontology
 GO:0005737; C:cytoplasm; ISA:MGI.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW. 
Interpro
 IPR006607; DM15.
 IPR006630; Lupus_La_RNA-bd.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF05383; La 
SMART
 SM00684; DM15
 SM00715; LA 
PROSITE
 PS50961; HTH_LA 
PRINTS