CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040843
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Peroxisome biogenesis factor 2 
Protein Synonyms/Alias
  
Gene Name
 PAF1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
24SGVVCRVKYCNSLPDubiquitination[1, 2]
52QNRFVQYKATSLEKQubiquitination[1, 3]
96LLDPADEKLLEEEIQubiquitination[3, 4, 5]
319TNALLVVKHRDMNEKubiquitination[3]
326KHRDMNEKELEAQEAubiquitination[2, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 462 AA 
Protein Sequence
MAPTIQTQAQ REDGHRSGVV CRVKYCNSLP DIPFDPKFIT YPFDQNRFVQ YKATSLEKQH 60
KHDLLTEPDL GVTIDLINPD TYRIDPNVLL DPADEKLLEE EIQAPTSSKR SQQHAKVVPW 120
MRKTEYISTE FNRYGISNEK PEVKIGVSVK QQFTEEEIYK DRDSQITAIE KTFEDAQKSM 180
WINPCAQVIF DSDPAPKDTS GAAALEMMSQ AMIRGMMDEE GNQFVAYFLP VEETLKKRKR 240
DQEEEMDYAP DDVYDYKIAR EYNWNVKNKA SKGYEENYFF IFREGDGVYY NELETRVRLS 300
KRRAKAGVQS GTNALLVVKH RDMNEKELEA QEARKAQLEN HEPEEEEEEE METEEKEAGG 360
SVMLILRTMP TLMMRTEDRP KVAVTMIQTA AAMGVASGAG ATAAAPVPSP VAASTRPRRM 420
AVKLQLLIPV KLIVTVTESQ GIQGWFRHHY CEQQSTFLVV CL 462 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA. 
Interpro
 IPR007133; RNA_pol_II-assoc_Paf1. 
Pfam
 PF03985; Paf1 
SMART
  
PROSITE
  
PRINTS