UniProt Accession

 SYN1_MOUSE; O88935; Q62279; Q8QZT8 

Genbank Protein ID

 AF085809; BC022954; L32025 

Genbank Nucleotide ID

 AAD09833.1; AAH22954.1; AAA79963.1 

Protein Name

 Synapsin-1 

Protein Synonyms/Alias

 Synapsin I 

Gene Name

 Syn1 

Gene Synonyms/Alias

 Syn-1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
128	EPHTDWAKYFKGKKI	ubiquitination	[1]
179	VKVVRSLKPDFVLIR	ubiquitination	[1]
238	QMVRLHKKLGTEEFP	ubiquitination	[1]
256	QTFYPNHKEMLSSTT	ubiquitination	[1]
281	HSGMGKVKVDNQHDF	ubiquitination	[1]
311	AEPFIDAKYDVRVQK	ubiquitination	[1]
318	KYDVRVQKIGQNYKA	ubiquitination	[1]
336	TSVSGNWKTNTGSAM	ubiquitination	[1]
576	ISGPAPTKASGAPPG	ubiquitination	[1]
593	QRQGPPQKPPGPAGP	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. Regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxide functions at a presynaptic level. 

Sequence Annotation

 REGION 1 28 A.
 REGION 29 112 B; linker.
 REGION 113 420 C; actin-binding and synaptic-vesicle
 REGION 421 657 D; Pro-rich linker.
 REGION 658 706 E.
 MOD_RES 9 9 Phosphoserine; by CaMK1 and PKA;
 MOD_RES 9 9 Phosphoserine; by PKA and CaMK1;
 MOD_RES 62 62 Phosphoserine.
 MOD_RES 67 67 Phosphoserine.
 MOD_RES 312 312 Phosphotyrosine.
 MOD_RES 337 337 Phosphothreonine.
 MOD_RES 427 427 Phosphoserine.
 MOD_RES 510 510 Phosphoserine.
 MOD_RES 512 512 Phosphothreonine.
 MOD_RES 520 520 Phosphoserine.
 MOD_RES 551 551 Phosphoserine; by PDPK1 (By similarity).
 MOD_RES 553 553 Phosphoserine.
 MOD_RES 568 568 Phosphoserine.
 MOD_RES 605 605 Phosphoserine; by CaMK2 (By similarity).
 MOD_RES 666 666 Phosphoserine.
 MOD_RES 705 705 Phosphoserine.
 CARBOHYD 55 55 O-linked (GlcNAc) (By similarity).
 CARBOHYD 56 56 O-linked (GlcNAc) (By similarity).
 CARBOHYD 87 87 O-linked (GlcNAc).
 CARBOHYD 96 96 O-linked (GlcNAc) (By similarity).
 CARBOHYD 103 103 O-linked (GlcNAc) (By similarity).
 CARBOHYD 261 261 O-linked (GlcNAc) (By similarity).
 CARBOHYD 432 432 O-linked (GlcNAc) (By similarity).
 CARBOHYD 518 518 O-linked (GlcNAc) (By similarity).
 CARBOHYD 526 526 O-linked (GlcNAc).
 CARBOHYD 564 564 O-linked (GlcNAc) (By similarity).
 CARBOHYD 578 578 O-linked (GlcNAc) (By similarity).  

Keyword

 Actin-binding; Alternative splicing; Cell junction; Complete proteome; Direct protein sequencing; Glycoprotein; Golgi apparatus; Phosphoprotein; Reference proteome; Repeat; Synapse. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 706 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0030425; C:dendrite; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0008021; C:synaptic vesicle; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0003824; F:catalytic activity; IEA:InterPro.
 GO:0008152; P:metabolic process; IEA:GOC.
 GO:0007269; P:neurotransmitter secretion; IEA:InterPro. 

Interpro

 IPR013815; ATP_grasp_subdomain_1.
 IPR013816; ATP_grasp_subdomain_2.
 IPR016185; PreATP-grasp_dom.
 IPR001359; Synapsin.
 IPR020898; Synapsin_ATP-bd_dom.
 IPR019735; Synapsin_CS.
 IPR019736; Synapsin_P_site.
 IPR020897; Synapsin_pre-ATP-grasp_dom. 

Pfam

 PF02078; Synapsin
 PF02750; Synapsin_C
 PF10581; Synapsin_N 

SMART

  

PROSITE

 PS00415; SYNAPSIN_1
 PS00416; SYNAPSIN_2 

PRINTS

 PR01368; SYNAPSIN.