UniProt Accession

 H15_RAT; D3ZBN0 

Genbank Protein ID

 AABR06092158; CH474072 

Genbank Nucleotide ID

 EDL84565.1 

Protein Name

 Histone H1.5 

Protein Synonyms/Alias

  

Gene Name

 Hist1h1b 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
17	TAPAPVEKSPAKKKT	acetylation	[1]
45	PVSELITKAVSASKE	acetylation	[1]
74	AGGYDVEKNNSRIKL	acetylation	[1]
80	EKNNSRIKLGLKSLV	acetylation	[1]
84	SRIKLGLKSLVSKGT	acetylation	[1]
89	GLKSLVSKGTLVQTK	acetylation	[1]
105	TGASGSFKLNKKVAS	acetylation	[1]
116	KVASGEAKPKAKKTG	acetylation	[1]
140	ATPKKPKKTAGAKKT	acetylation	[1]
145	PKKTAGAKKTVKKTP	acetylation	[1]
164	KPAAAGVKKVTKSPK	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). 

Sequence Annotation

 DOMAIN 35 108 H15.
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 2 2 Phosphoserine (By similarity).
 MOD_RES 4 4 Phosphothreonine (By similarity).
 MOD_RES 18 18 Phosphoserine (By similarity).
 MOD_RES 26 26 N6-methyllysine (By similarity).
 MOD_RES 35 35 Phosphothreonine (By similarity).
 MOD_RES 134 134 Phosphothreonine (By similarity).
 MOD_RES 164 164 N6-acetyllysine (By similarity).
 MOD_RES 169 169 Phosphoserine (By similarity).  

Keyword

 Acetylation; Chromosome; Complete proteome; DNA-binding; Methylation; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 222 AA 

Protein Sequence

Gene Ontology

 GO:0000790; C:nuclear chromatin; IEA:Compara.
 GO:0000786; C:nucleosome; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006334; P:nucleosome assembly; IEA:InterPro. 

Interpro

 IPR005818; Histone_H1/H5.
 IPR005819; Histone_H5.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00538; Linker_histone 

SMART

 SM00526; H15 

PROSITE

 PS51504; H15 

PRINTS

 PR00624; HISTONEH5.