CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030670
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mediator of RNA polymerase II transcription subunit 24 
Protein Synonyms/Alias
 cDNA FLJ59464, highly similar to Thyroid hormone receptor-associated proteincomplex 100 kDa component 
Gene Name
 MED24 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
85GTPAAGEKQLAMCLQubiquitination[1]
96MCLQRLEKTLSSTKNubiquitination[1]
279KLTPLLDKADQRCNCubiquitination[1]
401AAAAATGKLKSFARKubiquitination[1, 2]
403AAATGKLKSFARKFIubiquitination[1]
425YGSEESTKPASVRALubiquitination[1, 2]
479TCMPEEGKILNPDHPubiquitination[3]
579LGLDEREKSLQMIRQubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Receptor; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 638 AA 
Protein Sequence
MVSYSSVLTA ISKFDDFSRD LCVQALLDIM DMFCDRLSCH GKAEECIGLC RALLSALHWL 60
LRCTAASAER LREGLEAGTP AAGEKQLAMC LQRLEKTLSS TKNRALLHIA KLEEASSWTA 120
IEHSLLKLGE ILANLSNPQL RSQAEQCGTL IRSIPTMLSV HAEQMHKTGF PTVHAVILLE 180
GTMNLTGETQ SLVEQLTMVK RMQHIPTPLF VLEIWKACFV GLIESPEGTE ELKWTAFTFL 240
KIPQVLVKLK KYSHGDKDFT EDVNCAFEFL LKLTPLLDKA DQRCNCDCTN FLLQECGKQG 300
LLSEASVNNL MAKRKADREH APQQKSGENA NIQPNIQLIL RAEPTVTNIL KCSSGLDFLS 360
CPQTMDADHS KSPEGLLGVL GHMLSGKSLD LLLAAAAATG KLKSFARKFI NLNEFTTYGS 420
EESTKPASVR ALLFDISFLM LCHVAQTYGS EVILSESRTG AEVPFFETWM QTCMPEEGKI 480
LNPDHPCFRP DSTKVESLVA LLNNSSEMKL VQMKWHEACL SISAAILEIL NAWENGVLAF 540
ESIQKITDNI KGKVCSLAVC AVAWLVAHVR MLGLDEREKS LQMIRQLAGP LFSENTLQFY 600
NERVVIMNSI LERMCADVLQ QTATQIKFPS TGVDTMPY 638 
Gene Ontology
  
Interpro
 IPR021429; Mediator_Med24_N. 
Pfam
 PF11277; Med24_N 
SMART
  
PROSITE
  
PRINTS