CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016696
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Low density lipoprotein receptor adapter protein 1 
Protein Synonyms/Alias
 Autosomal recessive hypercholesterolemia protein homolog 
Gene Name
 Ldlrap1 
Gene Synonyms/Alias
 Arh 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
19IRSPSLAKQSWAGGRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. 
Sequence Annotation
 DOMAIN 41 195 PID.
 REGION 248 275 AP-2 complex binding (By similarity).
 MOTIF 211 215 Clathrin box.
 MOTIF 256 265 [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif.
 MOD_RES 14 14 Phosphoserine (By similarity).
 MOD_RES 198 198 Phosphoserine.  
Keyword
 Atherosclerosis; Cholesterol metabolism; Complete proteome; Cytoplasm; Endocytosis; Hyperlipidemia; Lipid metabolism; Phosphoprotein; Reference proteome; Steroid metabolism; Sterol metabolism. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 308 AA 
Protein Sequence
MDALKSAGRA LIRSPSLAKQ SWAGGRHRKL PENWTDTRET LLEGMVFSLK YLGMTLVERP 60
KGEELSAAAV KRIVATAKAS GKKLQKVTLK VSPRGIILTD SLTSQLIENV SIYRISYCTA 120
DKMHDKVFAY IAQSQQNESL ECHAFLCTKR KVAQAVTLTV AQAFKVAFEF WQVSKEEKEK 180
REKANQEGGD VPGTRRDSTP SLKTLVATGN LLDLEEVAKA PLSTVSANTN NVDETPRPQV 240
LGNNSVVWEL DDGLDEAFSR LAQSRTNPQV LDTGLSAQDI HYAQCLSPTD WDKPDSSGID 300
QDDDVFTF 308 
Gene Ontology
 GO:0030121; C:AP-1 adaptor complex; IEA:Compara.
 GO:0030122; C:AP-2 adaptor complex; IEA:Compara.
 GO:0009925; C:basal plasma membrane; ISS:UniProtKB.
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0005769; C:early endosome; IDA:MGI.
 GO:0009898; C:internal side of plasma membrane; IEA:Compara.
 GO:0005883; C:neurofilament; IDA:BHF-UCL.
 GO:0055037; C:recycling endosome; IEA:Compara.
 GO:0001540; F:beta-amyloid binding; IPI:BHF-UCL.
 GO:0030276; F:clathrin binding; ISS:UniProtKB.
 GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:Compara.
 GO:0001784; F:phosphotyrosine binding; ISS:UniProtKB.
 GO:0005102; F:receptor binding; ISA:MGI.
 GO:0035591; F:signaling adaptor activity; IEA:Compara.
 GO:0042982; P:amyloid precursor protein metabolic process; IEA:Compara.
 GO:0042632; P:cholesterol homeostasis; IMP:MGI.
 GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
 GO:0048260; P:positive regulation of receptor-mediated endocytosis; ISS:UniProtKB.
 GO:0031623; P:receptor internalization; IEA:Compara.
 GO:0090118; P:receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport; IEA:Compara.
 GO:0090003; P:regulation of establishment of protein localization to plasma membrane; IEA:Compara.
 GO:0043393; P:regulation of protein binding; IEA:Compara. 
Interpro
 IPR011993; PH_like_dom.
 IPR006020; PTyr_interaction_dom. 
Pfam
 PF00640; PID 
SMART
 SM00462; PTB 
PROSITE
 PS01179; PID 
PRINTS