UniProt Accession

 ATAD1_MOUSE; Q9D5T0; Q3U8V2; Q9D7A4 

Genbank Protein ID

 AK009419; AK014967; AK030719; AK033639; AK150469; AK152059; AK165953; BC029085; BC043051 

Genbank Nucleotide ID

 BAB26274.1; BAB29643.1; BAC27097.1; BAC28402.1; BAE29586.1; BAE30915.1; BAE38481.1; AAH29085.1; AAH43051.1 

Protein Name

 ATPase family AAA domain-containing protein 1 

Protein Synonyms/Alias

 Thorase 

Gene Name

 Atad1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
263	HINQPALKQREAILK	ubiquitination	[1]
274	AILKLILKNENVDRH	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA- stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent. 

Sequence Annotation

 NP_BIND 133 140 ATP (Potential).
 MOD_RES 322 322 Phosphoserine.
 CROSSLNK 46 46 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 ATP-binding; Cell junction; Cell membrane; Complete proteome; Hydrolase; Isopeptide bond; Membrane; Nucleotide-binding; Peroxisome; Phosphoprotein; Postsynaptic cell membrane; Reference proteome; Synapse; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 361 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005778; C:peroxisomal membrane; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0045211; C:postsynaptic membrane; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; IDA:UniProtKB.
 GO:0007612; P:learning; IMP:UniProtKB.
 GO:0007613; P:memory; IMP:UniProtKB.
 GO:0051967; P:negative regulation of synaptic transmission, glutamatergic; IMP:UniProtKB.
 GO:0002092; P:positive regulation of receptor internalization; IMP:UniProtKB. 

Interpro

 IPR003593; AAA+_ATPase.
 IPR003959; ATPase_AAA_core.
 IPR003960; ATPase_AAA_CS.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00004; AAA 

SMART

 SM00382; AAA 

PROSITE

 PS00674; AAA 

PRINTS