CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032104
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ephrin type-A receptor 4 
Protein Synonyms/Alias
 cDNA FLJ53205, highly similar to Ephrin type-A receptor 4 (EC 2.7.10.1) 
Gene Name
 EPHA4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
684RGIGSGMKYLSDMSYubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 935 AA 
Protein Sequence
MKWEEVSIMD EKNTPIRTYQ VCNVMEPSQN NWLRTDWITR EGAQRVYIEI KFTLRDCNSL 60
PGVMGTCKET FNLYYYESDN DKERFIRENQ FVKIDTIAAD ESFTQVDIGD RIMKLNTEIR 120
DVGPLSKKGF YLAFQDVGAC IALVSVRVFY KKCPLTVRNL AQFPDTITGA DTSSLVEVRG 180
SCVNNSEEKD VPKMYCGADG EWLVPIGNCL CNAGHEERSG ECQACKIGYY KALSTDATCA 240
KCPPHSYSVW EGATSCTCDR GFFRADNDAA SMPCTRPPSA PLNLISNVNE TSVNLEWSSP 300
QNTGGRQDIS YNVVCKKCGA GDPSKCRPCG SGVHYTPQQN GLKTTKVSIT DLLAHTNYTF 360
EIWAVNGVSK YNPNPDQSVS VTVTTNQAAP SSIALVQAKE VTRYSVALAW LEPDRPNGVI 420
LEYEVKYYEK DQNERSYRIV RTAARNTDIK GLNPLTSYVF HVRARTAAGY GDFSEPLEVT 480
TNTVPSRIIG DGANSTVLLV SVSGSVVLVV ILIAAFVISR RRSKYSKAKQ EADEEKHLNQ 540
GVRTYVDPFT YEDPNQAVRE FAKEIDASCI KIEKVIGVGE FGEVCSGRLK VPGKREICVA 600
IKTLKAGYTD KQRRDFLSEA SIMGQFDHPN IIHLEGVVTK CKPVMIITEY MENGSLDAFL 660
RKNDGRFTVI QLVGMLRGIG SGMKYLSDMS YVHRDLAARN ILVNSNLVCK VSDFGMSRVL 720
EDDPEAAYTT RGGKIPIRWT APEAIAYRKF TSASDVWSYG IVMWEVMSYG ERPYWDMSNQ 780
DVIKAIEEGY RLPPPMDCPI ALHQLMLDCW QKERSDRPKF GQIVNMLDKL IRNPNSLKRT 840
GTESSRPNTA LLDPSSPEFS AVVSVGDWLQ AIKMDRYKDN FTAAGYTTLE AVVHVNQEDL 900
ARIGITAITH QNKILSSVQA MRTQMQQMHG RMVPV 935 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005003; F:ephrin receptor activity; IEA:InterPro. 
Interpro
 IPR001090; Ephrin_rcpt_lig-bd_dom.
 IPR003961; Fibronectin_type3.
 IPR008979; Galactose-bd-like.
 IPR013783; Ig-like_fold.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001660; SAM.
 IPR013761; SAM/pointed.
 IPR011510; SAM_2.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom.
 IPR016257; Tyr_kinase_ephrin_rcpt.
 IPR001426; Tyr_kinase_rcpt_V_CS. 
Pfam
 PF01404; Ephrin_lbd
 PF00041; fn3
 PF07714; Pkinase_Tyr
 PF07647; SAM_2 
SMART
 SM00615; EPH_lbd
 SM00060; FN3
 SM00454; SAM
 SM00219; TyrKc 
PROSITE
 PS51550; EPH_LBD
 PS50853; FN3
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR
 PS00790; RECEPTOR_TYR_KIN_V_1
 PS00791; RECEPTOR_TYR_KIN_V_2
 PS50105; SAM_DOMAIN 
PRINTS
 PR00109; TYRKINASE.