UniProt Accession

 GABPA_MOUSE; Q00422; Q7TT22 

Genbank Protein ID

 M74515; AK139916; AK145446; AK145838; AK148087; AK150455; CH466521; BC052448 

Genbank Nucleotide ID

 AAA53030.1; BAE24181.1; BAE26442.1; BAE26687.1; BAE28337.1; BAE29575.1; EDK98317.1; AAH52448.1 

Protein Name

 GA-binding protein alpha chain 

Protein Synonyms/Alias

 GABP subunit alpha 

Gene Name

 Gabpa 

Gene Synonyms/Alias

 E4tf1a 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
359	QPELVAQKWGQRKNK	ubiquitination	[1]
398	QGKRFVYKFVCDLKT	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Transcription factor capable of interacting with purine rich repeats (GA repeats). 

Sequence Annotation

 DOMAIN 168 251 PNT.
 DNA_BIND 320 400 ETS.  

Keyword

 3D-structure; Complete proteome; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 454 AA 

Protein Sequence

Gene Ontology

 GO:0000790; C:nuclear chromatin; IEA:Compara.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0046982; F:protein heterodimerization activity; ISO:MGI.
 GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IEA:Compara.
 GO:0001228; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IEA:Compara.
 GO:0044212; F:transcription regulatory region DNA binding; ISO:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0045653; P:negative regulation of megakaryocyte differentiation; IMP:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISO:MGI. 

Interpro

 IPR000418; Ets_dom.
 IPR024668; GABP_asu_N.
 IPR003118; Pointed_dom.
 IPR013761; SAM/pointed.
 IPR016312; TF_GA-bd_asu.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00178; Ets
 PF11620; GABP-alpha
 PF02198; SAM_PNT 

SMART

 SM00413; ETS
 SM00251; SAM_PNT 

PROSITE

 PS00345; ETS_DOMAIN_1
 PS00346; ETS_DOMAIN_2
 PS50061; ETS_DOMAIN_3
 PS51433; PNT 

PRINTS

 PR00454; ETSDOMAIN.