UniProt Accession

 WDR92_HUMAN; Q96MX6; Q96CR6 

Genbank Protein ID

 AK056303; AC017083; BC014022; BC066657 

Genbank Nucleotide ID

 BAB71143.1; AAY14713.1; AAH14022.2; AAH66657.1 

Protein Name

 WD repeat-containing protein 92 

Protein Synonyms/Alias

 WD repeat-containing protein Monad 

Gene Name

 WDR92 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
6	**MSAFEKPQIIAHI	ubiquitination	[1, 2]
25	NYTVFDCKWVPCSAK	ubiquitination	[1]
32	KWVPCSAKFVTMGNF	ubiquitination	[1]
57	EIQHGDLKLLREIEK	ubiquitination	[1]
69	IEKAKPIKCGTFGAT	ubiquitination	[1]
111	VYSVKGHKEIINAID	ubiquitination	[1]
142	GSRDGTVKVWDPRQK	ubiquitination	[1]
149	KVWDPRQKDDPVANM	ubiquitination	[1]
164	EPVQGENKRDCWTVA	ubiquitination	[1]
193	GYDNGDIKLFDLRNM	ubiquitination	[1]
209	LRWETNIKNGVCSLE	ubiquitination	[1]
235	VATSLEGKFHVFDMR	ubiquitination	[1]
248	MRTQHPTKGFASVSE	ubiquitination	[1]
256	GFASVSEKAHKSTVW	ubiquitination	[1]
259	SVSEKAHKSTVWQVR	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Seems to act as a modulator of apoptosis. 

Sequence Annotation

 REPEAT 63 105 WD 1.
 REPEAT 115 154 WD 2.
 REPEAT 162 205 WD 3.
 REPEAT 207 249 WD 4.
 REPEAT 257 297 WD 5.
 REPEAT 319 357 WD 6.  

Keyword

 3D-structure; Alternative splicing; Apoptosis; Complete proteome; Polymorphism; Reference proteome; Repeat; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 357 AA 

Protein Sequence

Gene Ontology

 GO:0035064; F:methylated histone residue binding; IDA:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0034968; P:histone lysine methylation; IDA:UniProtKB. 

Interpro

 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS