CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043623
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Alanine--glyoxylate aminotransferase 2, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 Agxt2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
331QYPKEFLKEAFALVRacetylation[1, 2, 3]
331QYPKEFLKEAFALVRsuccinylation[2]
331QYPKEFLKEAFALVRubiquitination[4]
396VTTPEIAKSLAKRLLacetylation[1, 3, 5]
396VTTPEIAKSLAKRLLubiquitination[4]
444VGTYMLLKFAKLRDEacetylation[1, 2, 3, 6]
444VGTYMLLKFAKLRDEsuccinylation[2]
447YMLLKFAKLRDEFDIacetylation[1, 2, 3]
447YMLLKFAKLRDEFDIsuccinylation[2]
481ISRQPLPKTEVNQIHacetylation[1, 3]
492NQIHEDCKDMGLLVGacetylation[3]
Reference
 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [5] Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice.
 Fritz KS, Galligan JJ, Hirschey MD, Verdin E, Petersen DR.
 J Proteome Res. 2012 Mar 2;11(3):1633-43. [PMID: 22309199]
 [6] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Pyridoxal phosphate; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 541 AA 
Protein Sequence
MSLAWRNLQK PFYLETSLRI LQMRPSLSLG ASRIAVPKLT LHTKHSMPPC DFSPEKYQSL 60
AYSRVLAIHK QHLSPVDTAY FRKPLLLHQG HMEWLFDSEG NRYLDFFSGI VTVSVGHCHP 120
KVSAVAKKQI DRLWHTSSVF FHSPMHEYAE KLSALLPEPL KVIFLVNSGS EANDLAMVMA 180
RAHSNHTDII SFRGAYHGCS PYTLGLTNVG IYKMEVPGGI GCQSTMCPDV FRGPWGGIHC 240
RDSPVQTVRD CSCAPGPNGQ GGRRECHSNI KCCDLCMCVC FATDCCQAKE RYIEQFKDTL 300
NTSVATSIAG FFAEPIQGVN GVVQYPKEFL KEAFALVRER GGVCIADEVQ TGFGRLGSHF 360
WGFQTHDVLP DIVTMAKGIG NGFPMAAVVT TPEIAKSLAK RLLHFSTFGG NPLACAIGSA 420
VLEVIEEENL QRNSQEVGTY MLLKFAKLRD EFDIVGDVRG KGLMVGIEMV QDKISRQPLP 480
KTEVNQIHED CKDMGLLVGR GGNFSQTFRI VPPMCVTKME VDFAYEVFRA ALIQHMERRA 540
K 541 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0047305; F:(R)-3-amino-2-methylpropionate-pyruvate transaminase activity; IEA:Compara.
 GO:0008453; F:alanine-glyoxylate transaminase activity; IEA:Compara.
 GO:0016223; F:beta-alanine-pyruvate transaminase activity; IEA:Compara.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0019265; P:glycine biosynthetic process, by transamination of glyoxylate; IEA:Compara.
 GO:0009436; P:glyoxylate catabolic process; IEA:Compara.
 GO:0019481; P:L-alanine catabolic process, by transamination; IEA:Compara.
 GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Compara. 
Interpro
 IPR005814; Aminotrans_3.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 
Pfam
 PF00202; Aminotran_3 
SMART
  
PROSITE
 PS00600; AA_TRANSFER_CLASS_3 
PRINTS