UniProt Accession

 C9JX50_HUMAN; C9JX50 

Genbank Protein ID

 AC027288; AC073570; AC073572; AC073606; AC073616; AC078917; AC090709 

Genbank Nucleotide ID

  

Protein Name

 Synaptotagmin-1 

Protein Synonyms/Alias

  

Gene Name

 SYT1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
105	GKNAINMKDVKDLGK	ubiquitination	[1]
120	TMKDQALKDDDAETG	ubiquitination	[1, 2]
134	GLTDGEEKEEPKEEE	ubiquitination	[1, 2]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 182 AA 

Protein Sequence

Gene Ontology

 GO:0031045; C:dense core granule; IEA:Compara.
 GO:0060076; C:excitatory synapse; IEA:Compara.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0042734; C:presynaptic membrane; IEA:Compara.
 GO:0030672; C:synaptic vesicle membrane; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:Compara.
 GO:0005544; F:calcium-dependent phospholipid binding; IEA:Compara.
 GO:0005215; F:transporter activity; IEA:InterPro.
 GO:0017158; P:regulation of calcium ion-dependent exocytosis; IEA:Compara.
 GO:0016079; P:synaptic vesicle exocytosis; IEA:Compara. 

Interpro

 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR001565; Synaptotagmin.
 IPR015428; Synaptotagmin1. 

Pfam

  

SMART

  

PROSITE

  

PRINTS

 PR00399; SYNAPTOTAGMN.