UniProt Accession

 RHOF_HUMAN; Q9HBH0; Q8WVB1; Q9NXH6 

Genbank Protein ID

 AF239923; AK000254; BC018208 

Genbank Nucleotide ID

 AAG24952.1; BAA91034.1; AAH18208.1 

Protein Name

 Rho-related GTP-binding protein RhoF 

Protein Synonyms/Alias

 Rho family GTPase Rif; Rho in filopodia 

Gene Name

 RHOF 

Gene Synonyms/Alias

 ARHF; RIF 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
132	PMVLIGCKTDLRKDK	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin- based morphology. 

Sequence Annotation

 NP_BIND 26 33 GTP (By similarity).
 NP_BIND 73 77 GTP (By similarity).
 NP_BIND 131 134 GTP (By similarity).
 MOTIF 48 56 Effector region (Potential).
 MOD_RES 208 208 Cysteine methyl ester (Potential).
 LIPID 208 208 S-geranylgeranyl cysteine (Potential).  

Keyword

 Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Prenylation; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 211 AA 

Protein Sequence

Gene Ontology

 GO:0005856; C:cytoskeleton; NAS:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; NAS:UniProtKB.
 GO:0007015; P:actin filament organization; IDA:UniProtKB.
 GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.
 GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003578; Small_GTPase_Rho. 

Pfam

 PF00071; Ras 

SMART

 SM00174; RHO 

PROSITE

 PS51420; RHO 

PRINTS

 PR00449; RASTRNSFRMNG.