UniProt Accession

 THEM4_RAT; Q566R0 

Genbank Protein ID

 BC093385 

Genbank Nucleotide ID

 AAH93385.1 

Protein Name

 Acyl-coenzyme A thioesterase THEM4 

Protein Synonyms/Alias

 Acyl-CoA thioesterase THEM4; Thioesterase superfamily member 4 

Gene Name

 Them4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
46	LPNPSWTKDLRLLFD	acetylation	[1]
57	LLFDQFMKKCEDGSW	acetylation	[1]
98	KKEEQMSKAQQFTRS	acetylation	[1]
222	QATALFIKLDPDKPL	acetylation	[1]
227	FIKLDPDKPLT****	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays an role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity (By similarity). 

Sequence Annotation

 REGION 196 197 Substrate binding (By similarity).
 ACT_SITE 152 152 Proton donor/acceptor (By similarity).
 BINDING 175 175 Substrate (By similarity).
 MOD_RES 28 28 Phosphoserine (By similarity).
 MOD_RES 29 29 Phosphoserine (By similarity).  

Keyword

 Apoptosis; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Fatty acid metabolism; Hydrolase; Lipid metabolism; Membrane; Mitochondrion; Mitochondrion inner membrane; Phosphoprotein; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 230 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
 GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; ISS:UniProtKB.
 GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
 GO:0016290; F:palmitoyl-CoA hydrolase activity; ISS:UniProtKB.
 GO:0006631; P:fatty acid metabolic process; ISS:UniProtKB.
 GO:0043491; P:protein kinase B signaling cascade; ISS:UniProtKB.
 GO:1902108; P:regulation of mitochondrial membrane permeability involved in apoptotic process; ISS:UniProtKB. 

Interpro

 IPR006683; Thioestr_supf. 

Pfam

 PF03061; 4HBT 

SMART

  

PROSITE

  

PRINTS