UniProt Accession

 ETV7_HUMAN; Q9Y603; B3KVC2; B4DVB6; B4E1G4; Q5R3L3; Q5R3L4; Q9NZ65; Q9NZ66; Q9NZ68; Q9NZR8; Q9UNJ7; Q9Y5K4; Q9Y604 

Genbank Protein ID

 AF116508; AF116509; AF116510; AF218235; AF218365; AF218366; AF175387; AF147782; AJ276205; AK122796; AK301011; AK303829; Z84484; Z84484; CH471081; CH471081; CH471081; BC035853 

Genbank Nucleotide ID

 AAD43250.1; AAD43251.1; AAD43252.1; AAF28350.1; AAF44742.1; AAF44743.1; AAF25007.3; AAD33989.1; CAC17012.1; BAG53734.1; BAG62628.1; BAG64776.1; CAI21615.1; CAI21616.1; EAX03885.1; EAX03888.1; EAX03890.1; AAH35853.1 

Protein Name

 Transcription factor ETV7 

Protein Synonyms/Alias

 ETS translocation variant 7; ETS-related protein Tel2; Tel-related Ets factor; Transcription factor Tel-2 

Gene Name

 ETV7 

Gene Synonyms/Alias

 TEL2; TELB; TREF 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
293	YYKLNIIKKEPGQKL	ubiquitination	[1, 2]
294	YKLNIIKKEPGQKLL	ubiquitination	[1, 2]
310	RFLKTPGKMVQDKHS	methylation	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 

Functional Description

 Transcriptional repressor; binds to the DNA sequence 5'- CCGGAAGT-3'. Isoform A does not seem to have a repressor activity. Isoform C does not seem to have a repressor activity. 

Sequence Annotation

 DOMAIN 33 117 PNT.
 DNA_BIND 224 305 ETS.  

Keyword

 Alternative splicing; Complete proteome; DNA-binding; Nucleus; Polymorphism; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 341 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:HPA.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0009887; P:organ morphogenesis; TAS:ProtInc.
 GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc. 

Interpro

 IPR000418; Ets_dom.
 IPR003118; Pointed_dom.
 IPR013761; SAM/pointed.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00178; Ets
 PF02198; SAM_PNT 

SMART

 SM00413; ETS
 SM00251; SAM_PNT 

PROSITE

 PS00345; ETS_DOMAIN_1
 PS00346; ETS_DOMAIN_2
 PS50061; ETS_DOMAIN_3
 PS51433; PNT 

PRINTS

 PR00454; ETSDOMAIN.