CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033653
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 L-2-hydroxyglutarate dehydrogenase, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 L2HGDH 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
104IHSGIYYKPESLKAKacetylation[1, 2]
155RLQALYEKGLQNGVPacetylation[1, 2, 3]
155RLQALYEKGLQNGVPubiquitination[4]
173LIQQEDIKKKEPYCRacetylation[1]
226VKGIEMAKESPSRSIubiquitination[4]
246PIVIKNTKGEEIRCQubiquitination[4]
297PEKCYLVKGNIYPVPubiquitination[4]
Reference
 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 441 AA 
Protein Sequence
MVPALRYLVG ACGRARGLFA GGSPGACGFA SGRPRPLCGG SRSASTSSFD IVIVGGGIVG 60
LASARALILR HPSLSIGVLE KEKDLAVHQT GHNSGVIHSG IYYKPESLKA KLCVQGAALL 120
YEYCQQKGIS YKQCGKLIVA VEQEEIPRLQ ALYEKGLQNG VPGLRLIQQE DIKKKEPYCR 180
GLMAIDCPHT GIVDYRQVAL SFAQDFQEAG GSVLTNFEVK GIEMAKESPS RSIDGMQYPI 240
VIKNTKGEEI RCQYVVTCAG LYSDRISELS GCTPDPRIVP FRGDYLLLKP EKCYLVKGNI 300
YPVPDSRFPF LGVHFTPRMD GSIWLGPNAV LAFKREGYRP FDFSATDVMD IIINSGLIKL 360
ASQNFSYGVT EMYKACFLGA TVKYLQKFIP EITISDILRQ VAVRGPSWLW QQPMKVSDNN 420
IYCFLWRCFA LLLTGSACSF K 441 
Gene Ontology
 GO:0016491; F:oxidoreductase activity; IEA:InterPro. 
Interpro
 IPR006076; FAD-dep_OxRdtase. 
Pfam
 PF01266; DAO 
SMART
  
PROSITE
  
PRINTS