UniProt Accession

 J3QQ26_MOUSE; J3QQ26 

Genbank Protein ID

 AC121967; CH466534 

Genbank Nucleotide ID

 EDL41327.1 

Protein Name

 Proliferating cell nuclear antigen 

Protein Synonyms/Alias

  

Gene Name

 Pcna-ps2 

Gene Synonyms/Alias

 mCG_118515 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
13	LIQGSILKKVLEALK	acetylation	[1]
77	VNLTSMSKILKCAGN	acetylation	[1]
80	TSMSKILKCAGNEDI	acetylation	[1, 2]
80	TSMSKILKCAGNEDI	succinylation	[2]
80	TSMSKILKCAGNEDI	ubiquitination	[3]
164	AVVISCAKNGVKFSA	ubiquitination	[3]
248	IADMGHLKYYLAPKI	acetylation	[1, 2]
248	IADMGHLKYYLAPKI	succinylation	[2]
248	IADMGHLKYYLAPKI	ubiquitination	[3]
254	LKYYLAPKIEDEEAS	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; DNA replication; DNA-binding; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 261 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0043626; C:PCNA complex; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0030337; F:DNA polymerase processivity factor activity; IEA:InterPro.
 GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
 GO:0006275; P:regulation of DNA replication; IEA:InterPro. 

Interpro

 IPR000730; Pr_cel_nuc_antig.
 IPR022649; Pr_cel_nuc_antig_C.
 IPR022659; Pr_cel_nuc_antig_CS.
 IPR022648; Pr_cel_nuc_antig_N. 

Pfam

 PF02747; PCNA_C
 PF00705; PCNA_N 

SMART

  

PROSITE

 PS01251; PCNA_1
 PS00293; PCNA_2 

PRINTS

 PR00339; PCNACYCLIN.