UniProt Accession

 HNRPM_HUMAN; P52272; Q15584; Q8WZ44; Q96H56; Q9BWL9; Q9Y492 

Genbank Protein ID

 L03532; L32611; AF061832; BC000138; BC008895; BC019580 

Genbank Nucleotide ID

 AAA36192.1; AAL31359.1; AAC16002.1; AAH00138.2; AAH08895.2; AAH19580.1 

Protein Name

 Heterogeneous nuclear ribonucleoprotein M 

Protein Synonyms/Alias

 hnRNP M 

Gene Name

 HNRNPM 

Gene Synonyms/Alias

 HNRPM; NAGR1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
37	GNGAPGPKGEGERPA	ubiquitination	[1]
48	ERPAQNEKRKEKNIK	ubiquitination	[1]
69	EPYANPTKRYRAFIT	ubiquitination	[1]
83	TNIPFDVKWQSLKDL	ubiquitination	[1]
88	DVKWQSLKDLVKEKV	ubiquitination	[1]
110	LLMDAEGKSRGCAVV	ubiquitination	[1]
134	KAAEVLNKHSLSGRP	ubiquitination	[1]
200	RADILEDKDGKSRGI	ubiquitination	[1]
203	ILEDKDGKSRGIGTV	ubiquitination	[1]
306	GIGFGINKMGGMEGP	ubiquitination	[1]
342	EILSNALKRGEIIAK	ubiquitination	[1]
349	KRGEIIAKQGGGGGG	ubiquitination	[1]
628	LPFDFTWKMLKDKFN	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. 

Sequence Annotation

 DOMAIN 71 149 RRM 1.
 DOMAIN 204 281 RRM 2.
 REPEAT 400 405 1.
 REPEAT 407 412 2.
 REPEAT 415 420 3.
 REPEAT 426 431 4.
 REPEAT 433 438 5.
 REPEAT 440 445 6.
 REPEAT 446 451 7.
 REPEAT 453 458 8.
 REPEAT 461 466 9.
 REPEAT 468 473 10.
 REPEAT 475 480 11.
 REPEAT 482 487 12.
 REPEAT 493 498 13.
 REPEAT 500 505 14.
 REPEAT 507 512 15.
 REPEAT 514 519 16.
 REPEAT 521 526 17.
 REPEAT 528 533 18.
 REPEAT 540 545 19.
 REPEAT 547 552 20.
 REPEAT 554 559 21.
 REPEAT 562 567 22.
 REPEAT 567 572 23.
 REPEAT 575 580 24.
 REPEAT 580 585 25.
 REPEAT 588 593 26.
 REPEAT 603 608 27.
 DOMAIN 653 729 RRM 3.
 REGION 400 608 27 X 6 AA repeats of [GEVSTPAN]-[ILMV]-
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 29 29 Phosphoserine.
 MOD_RES 277 277 N6-acetyllysine.
 MOD_RES 432 432 Phosphoserine.
 MOD_RES 452 452 Phosphoserine.
 MOD_RES 468 468 Phosphoserine.
 MOD_RES 481 481 Phosphoserine.
 MOD_RES 528 528 Phosphoserine.
 MOD_RES 575 575 Phosphoserine.
 MOD_RES 588 588 Phosphoserine.
 MOD_RES 618 618 Phosphoserine.
 MOD_RES 633 633 Phosphoserine.
 MOD_RES 637 637 Phosphoserine.
 MOD_RES 698 698 N6-acetyllysine.
 MOD_RES 701 701 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding; Spliceosome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 730 AA 

Protein Sequence

Gene Ontology

 GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0016363; C:nuclear matrix; IDA:BHF-UCL.
 GO:0042382; C:paraspeckles; IDA:BHF-UCL.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; NAS:HGNC.
 GO:0000380; P:alternative mRNA splicing, via spliceosome; IMP:BHF-UCL. 

Interpro

 IPR024667; HnRNP_M.
 IPR024666; HnRNP_M_PY-NLS.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF11532; HnRNP_M
 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS